Abstract:Objective To discuss the progress on MRI in evaluating the response of hepatocellular carcinoma after transcatheter arterial chemoembolization (TACE). Methods The literatures related to the evaluations of TACE for HCC from January 1990 to March 2016 were searched and analyzed in CBM, PubMed and Embase with key words “hepatocellular carcinoma”, “transcatheter arterial chemoembolization” and “magnetic resonance imaging”. Results There are many types of MRI, contributing to evaluate the efficacy of TACE for HCC by plain scan, contrast-enhanced MRI and various fMRI, monitoring water diffusion, blood supply, metabolism and blood oxygen level; however, the widely clinical application on clinic are restrained due to the disadvantages of each MRI. Conclusions MRI plays an important role in assessing the effects of TACE for hepatocellular carcinoma, especially when two or more MRI types are combined. With the further study and development of the technology, MRI will become an unparalleled method in evaluating the efficacy of TACE for HCC.
翟天宇,王健东. MRI评估肝细胞癌经导管动脉化疗栓塞术疗效的研究进展[J]. 中华解剖与临床杂志, 2017, 22(3): 244-247.
Zhai Tianyu,Wang Jiandong. The application of MRI in evaluating the therapeutic efficacy of transcatheter arterial chemoembolization for hepatocellular carcinoma. Chinese Journal of Anatomy and Clinics, 2017, 22(3): 244-247.
Fitzmorris P, Shoreibah M, Anand BS, et al.Management of hepatocellular carcinoma[J].J Cancer Res Clin Oncol, 2015, 141(5): 861-876.DOI:10.1007/s00432-014-1806-0
[2]
Goshima S, Kanematsu M, Kondo H, et al.Evaluating local hepatocellular carcinoma recurrence post-transcatheter arterial chemoembolization: is diffusion-weighted MRI reliable as an indicator[J].J Magn Reson Imaging, 2008, 27(4): 834-839.DOI:10.1002/jmri.21316
[3]
Prajapati HJ, Spivey JR, Hanish SI, et al.mRECIST and EASL responses at early time point by contrast-enhanced dynamic MRI predict survival in patients with unresectable hepatocellular carcinoma (HCC) treated by doxorubicin drug-eluting beads transarterial chemoembolization (DEB TACE)[J].Ann Oncol, 2013, 24(4): 965-973.DOI:10.1093/annonc/mds605
Huang W, Li X, Morris E A, et al.The magnetic resonance shutter speed discriminates vascular properties of malignant and benign breast tumors in vivo[J].Proc Natl Acad Sci USA, 2008, 105(46): 17943-17948.DOI:10.1073/pnas.0711226105
[6]
Minami Y, Kudo M.Therapeutic response assessment of transcatheter arterial chemoembolization for hepatocellular carcinoma: ultrasonography, CT and MR imaging[J].Oncology, 2013, 84(Suppl 1): 58-63.DOI:10.1159/000345891
[7]
Gonzalez-Guindalini FD, Botelho MP, Harmath CB, et al.Assessment of liver tumor response to therapy: role of quantitative imaging[J].Radiographics, 2013, 33(6): 1781-1800.DOI:10.1148/rg.336135511
[8]
Choi Y, Huh J, Woo DC, et al.Use of gadoxetate disodium for functional MRI based on its unique molecular mechanism[J].Br J Radiol, 2016, 89(1058): 20150666.DOI:10.1259/bjr.20150666
[9]
Channual S, Pahwa A, Lu DS, et al.Enhancements in hepatobiliary imaging: the spectrum of gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid usages in hepatobiliary magnetic resonance imaging[J].Abdom Radiol (NY), 2016, 41(9): 1825-1841.DOI:10.1007/s00261-016-0767-y
[10]
Van Beers BE, Pastor CM, Hussain HK.Primovist, Eovist: what to expect?[J].J Hepatol, 2012, 57(2): 421-429.DOI:10.1016/j.jhep.2012.01.031
[11]
Ishimaru H, Nakashima K, Sakugawa T, et al.Local recurrence after chemoembolization of hepatocellular carcinoma: uptake of gadoxetic acid as a new prognostic factor[J].AJR Am J Roentgenol, 2014, 202(4): 744-751.DOI:10.2214/AJR.13.10848
[12]
Xu C, Sobhani F, Murano E, et al.Liver malignancies treated with intra-arterial therapy: assessment of early response as quantified by volumetric enhancement osing Gadoxetate disodium[J].J Comput Assist Tomogr, 2016, 40(2): 206-211.DOI:10.1097/RCT.0000000000000348
[13]
Xiao YD, Paudel R, Liu H, et al.Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: a potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization[J].Oncol Lett, 2015, 9(3): 1191-1196.DOI:10.3892/ol.2014.2826
[14]
Corona-Villalobos CP, Kamel IR.Functional volumetric MRI in assessing treatment response to intra-arterial therapy of primary and secondary liver tumors[J].J Comput Assist Tomogr, 2014, 38(4): 513-517.DOI:10.1097/RCT.0000000000000072
[15]
Bains LJ, Zweifel M, Thoeny HC.Therapy response with diffusion MRI: an update[J].Cancer Imaging, 2012, 12: 395-402.DOI:10.1102/1470-7330.2012.9047
[16]
Bonekamp D, Bonekamp S, Halappa VG, et al.Interobserver agreement of semi-automated and manual measurements of functional MRI metrics of treatment response in hepatocellular carcinoma[J].Eur J Radiol, 2014, 83(3): 487-496.DOI:10.1016/j.ejrad.2013.11.016
[17]
Kamel IR, Bluemke DA, Ramsey D, et al.Role of diffusion-weighted imaging in estimating tumor necrosis after chemoembolization of hepatocellular carcinoma[J].AJR Am J Roentgenol, 2003, 181(3): 708-710.DOI:10.2214/ajr.181.3.1810708
[18]
Mannelli L, Kim S, Hajdu CH, et al.Serial diffusion-weighted MRI in patients with hepatocellular carcinoma: prediction and assessment of response to transarterial chemoembolization.preliminary experience[J].Eur J Radiol, 2013, 82(4): 577-582.DOI:10.1016/j.ejrad.2012.11.026
[19]
Dong S, Ye XD, Yuan Z, et al.Relationship of apparent diffusion coefficient to survival for patients with unresectable primary hepatocellular carcinoma after chemoembolization[J].Eur J Radiol, 2012, 81(3): 472-477.DOI:10.1016/j.ejrad.2010.12.081
[20]
Le Bihan D.Diffusion, confusion and functional MRI[J].Neuroimage, 2012, 62(2): 1131-1136.DOI:10.1016/j.neuroimage.2011.09.058
Yoon JH, Lee JM, Yu MH, et al.Evaluation of hepatic focal lesions using diffusion-weighted MR imaging: comparison of apparent diffusion coefficient and intravoxel incoherent motion-derived parameters[J].J Magn Reson Imaging, 2014, 39(2): 276-285.DOI:10.1002/jmri.24158
[23]
Youn BJ, Chung JW, Son KR, et al.Diffusion-weighted MR: therapeutic evaluation after chemoembolization of VX-2 carcinoma implanted in rabbit liver[J].Acad Radiol, 2008, 15(5): 593-600.DOI:10.1016/j.acra.2007.10.022
[24]
Benndorf M, Schelhorn J, Dietzel M, et al.Diffusion weighted imaging of liver lesions suspect for metastases: apparent diffusion coefficient (ADC) values and lesion contrast are independent from Gd-EOB-DTPA administration[J].Eur J Radiol, 2012, 81(8): e849-e853.DOI:10.1016/j.ejrad.2012.03.027
[25]
Zhao JG, Feng GS, Kong XQ, et al.Changes of tumor microcirculation after transcatheter arterial chemoembolization: first pass perfusion MR imaging and Chinese ink casting in a rabbit model[J].World J Gastroenterol, 2004, 10(10): 1415-1420.DOI:10.3748/wjg.v10.i10.1415
[26]
Wang D, Gaba RC, Jin B, et al.Intraprocedural transcatheter intra-arterial perfusion MRI as a predictor of tumor response to chemoembolization for hepatocellular carcinoma[J].Acad Radiol, 2011, 18(7): 828-836.DOI:10.1016/j.acra.2011.02.016
[27]
Jin B, Wang D, Lewandowski RJ, et al.Quantitative 4D transcatheter intraarterial perfusion MRI for standardizing angiographic chemoembolization endpoints[J].AJR Am J Roentgenol, 2011, 197(5): 1237-1243.DOI:10.2214/AJR.10.5821
[28]
Wang D, Jin B, Lewandowski RJ, et al.Quantitative 4D transcatheter intraarterial perfusion MRI for monitoring chemoembolization of hepatocellular carcinoma[J].J Magn Reson Imaging, 2010, 31(5): 1106-1116.DOI:10.1002/jmri.22155
[29]
Kuo YT, Li CW, Chen CY, et al.In vivo proton magnetic resonance spectroscopy of large focal hepatic lesions and metabolite change of hepatocellular carcinoma before and after transcatheter arterial chemoembolization using 3.0-T MR scanner[J].J Magn Reson Imaging, 2004, 19(5): 598-604.DOI:10.1002/jmri.20046
[30]
Bian DJ, Xiao EH, Hu DX, et al.Magnetic resonance spectroscopy on hepatocellular carcinoma after transcatheter arterial chemoembolization[J].Chin J Cancer, 2010, 29(2): 198-201.DOI:10.5732/cjc.009.10312
[31]
Bonekamp S, Jolepalem P, Lazo M, et al.Hepatocellular carcinoma: response to TACE assessed with semiautomated volumetric and functional analysis of diffusion-weighted and contrast-enhanced MR imaging data[J].Radiology, 2011, 260(3): 752-761.DOI:10.1148/radiol.11102330
[32]
Chapiro J, Lin M, Duran R, et al.Assessing tumor response after loco-regional liver cancer therapies: the role of 3D MRI[J].Expert Rev Anticancer Ther, 2015, 15(2): 199-205.DOI:10.1586/14737140.2015.978861
[33]
Ogawa S, Lee TM, Kay AR, et al.Brain magnetic resonance imaging with contrast dependent on blood oxygenation[J].Proc Natl Acad Sci USA, 1990, 87(24): 9868-9872.DOI:10.1073/pnas.87.24.9868
[34]
Choi JW, Kim H, Kim HC, et al.Blood oxygen level-dependent MRI for evaluation of early response of liver tumors to chemoembolization: an animal study[J].Anticancer Res, 2013, 33(5): 1887-1892