Abstract:Objective To explore the application value of qualitative, semi-quantitative and quantitative parameters in dynamic enhanced MRI(DCE-MRI)in the diagnosis of pituitary adenoma.Methods The retrospective case-control study was conducted. The pituitary adenomas were collected in the First Affiliated Hospital of Bengbu Medical College from August 2014 to March 2018. Twenty-three cases of pituitary adenomas confirmed by clinical and pathological diagnosis were examined by DCE-MRI, including 9 males and 14 females with age of 29-70 years. Among them, there were 9 cases of microadenoma (microadenoma group) and 14 cases of macroadenoma (macroadenoma group). Eight cases of normal pituitary were selected as a control group, including 3 males and 5 females with ages of 28-67 years. Then obtain time-signal intensity curve (TIC) of these cases which consequently were classification and qualitatively analyzed. The time to peak (TTP), maximum slope of increase (MSI), volume transfer constant (Ktrans) and exchange rate constant (Kep) were measured. The single factor variance analysis and Kruskal-Wallis test were used for the above parameter.Results The number of microadenomas TIC three types of curves were 0, 7, 2; macroadenoma were 10, 3, 1; normal pituitary were 7, 1, 0. Difference was statistically significant(Z=11.346, P<0.01). Compared with other three groups, the TIC types in the control group were significantly different (all P values<0.05). The values of TTP [(48.52±15.83)s] with control group less than the microadenoma group [(80.79±19.32)s] and macroadenoma group[(70.42±21.64)s]; MSI(3.92%±1.24%), Ktrans [(1.08±0.22)min-1] and Kep[(1.34±0.40)min-1] of control group higher than microadenoma group [1.89%±1.04%,(0.45±0.18)min-1,(0.86±0.22)min-1] and macroadenoma group [2.79%±1.06%, (0.69±0.28)min-1, (0.95±0.28)min-1], the differences were statistically significant(all P values<0.05). The MSI and Ktrans values of macroadenoma were higher than those of microadenomas, the differences were statistically significant(all P values<0.05).Conclusions The TIC types can be used in differential diagnosis of pituitary adenoma. The TTP, MSI, Ktrans and Kep parameters can be further used to diagnose microadenomas. The parameters of Slopemax and Ktrans can be used in differential diagnosis of microadenoma and macroadenoma.
马宜传, 谢宗玉,. 动态增强MRI在垂体腺瘤诊断中的应用[J]. 中华解剖与临床杂志, 2018, 23(4): 288-292.
Ma Yichuan, Xie Zongyu.. The value of dynamic contrast enhancement MRI in diagnosis of pituitary adenoma. Chinese Journal of Anatomy and Clinics, 2018, 23(4): 288-292.
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