Abstract：Objective To investigate the clinical and pathological characteristics, immunophenotype and differential diagnosis of myofibroma.Methods The clinical data, histopathological features and immunohistochemical expression of a case of adult myofibroma which occurred in the sheath of common nerve in February 2017 were analyzed retrospectively. The literatures about the adult myofibroma of lower limbs before July 2018 were searched in PubMed, CNKI, Weipu and Wanfang database by using “adult” and “myofibroma” as the key words. Four cases reported in English and 1 case reported in Chinese were detected. The clinical findings, histopathological and immunohistochemical features, treatment and prognosis of 5 cases reported in literature and 1 case in this paper were analyzed.Results The patient's operation was successful, followed up for 1.5 years without recurrence. Six patients with adult myofibroma in the lower limb were analyzed, including 1 case in this paper and 5 cases reported, 2 males and 4 females, age ranged from 38 to 71 years. All cases presented with a solitary, well defined, cutaneous nodule. The nodule of one patient was located in the sheath of the common peroneal nerve.Another patient presented with an ulcerated lesion on the sole of her foot. Microscopically, all cases showed a biphasic pattern. Immunohistochemically, all cases showed positive expression of smooth muscle actin and negative expression of desmin, S-100, CD34 and showed low proliferation index of Ki-67.Conclusions Adult myofibroma is a rare benign soft tissue tumor occurring in lower limb. Its pathological features are biphasic pattem. The diagnosis of myofibroma depends on histomorphology and immunohistochemistry. It should be differentiated from other mesenchymal tumors.
龚春香, 范松龙, 邵馨. 发生于下肢的成人肌纤维瘤一例临床病理分析及文献复习[J]. 中华解剖与临床杂志, 2018, 23(6): 522-525.
Gong Chunxiang, Fan Songlong, Shao Xin.. Clinicopathologic analysis of myofibroma of lower limb in adult: a case report and review of the literatures. Chinese Journal of Anatomy and Clinics, 2018, 23(6): 522-525.
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2018, Vol. 23 
