Application value of the ultraphonic ultrafast pulse wave velocity technique for the quantitative evaluation of the carotid elastic changes in patients with type 2 diabetes mellitus
Zhu Min1, Li Yang1, Du Xiaoying1, Guo Jie1, Su Lei1, Cheng Li2, Zhu Yinghui3, Sun Yixue1
1Department of Ultrasound, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China; 2Department of Ultrasound, the First People's Hospital of Mengcheng, Mengcheng 233500, China; 3Department of Ultrasound, Huangshan City People's Hospital, Huangshan 245000, China
Abstract：Objective This study aimed to explore the application value of the ultraphonic ultrafast pulse wave velocity (UFPWV) technique in the quantitative evaluation of the carotid vascular wall elasticity changes of patients with type 2 diabetes mellitus.Methods This retrospective study included the imaging data of 97 cases of type 2 diabetes mellitus admitted at the First Affiliated Hospital of Bengbu Medical College in Anhui Province from July 2018 to March 2019 as the observation group. The cases consisted of 47 males and 50 females aged between 20 and 74 (46.6±9.3) years. In accordance with the carotid intima-media thickness (IMT), the observation group was divided into carotid atherosclerotic plaque group(groups A), carotid IMT thickening group(group B), and IMT normal group(group C). Group C was divided further into lower extremity atherosclerotic plaque group(group C1) and lower extremity arteries without plaque group(group C2) on the basis of the lower extremity arteries with or without plaque. A total of 64 volunteers with normal blood glucose and IMT were selected as the control group. The control group included 25 males and 39 females aged between 20 and 74 (44.3±12.0). The pulse wave velocity (PWV) was acquired via the ultrafast pulse wave technique, which included the beginning and ending of the systole (BS and ES, respectively), and the differences between the parameters were analyzed.Results In the observation group, the PWV-BS and the PWV-ES values were (9.51±1.25)and (10.79±1.64)m/s, respectively, in group A; (8.47±0.91) and (9.81±1.05) m/s, respectively, in group B; and (7.97±0.77) and (9.07±0.74) m/s, respectively, in group C. The PWV-BS and the PWV-ES values in the control group were (6.10±1.00) and 7.40±1.20 m/s, respectively. The results of carotid artery PWV-BS and PWV-ES in groups A, B, and C and the control group gradually decreased, and the differences were statistically significant (all P values<0.05). Within group C, the PWV-BS and the PWV-ES values were (7.83±0.85) and (8.82±0.59) m/s, respectively, in group C1 and (8.14±0.64) and (9.34±0. 79) m/s, respectively, in group C2. The PWV-ES in group C1 was significantly higher than that in group C2 (t=3.402, P<0.01). By contrast, no statistical significance on the PWV-BS values existed between the two groups (P>0.05).Conclusions The UFPWV technique can be used to evaluate the carotid elastic changes in patients with type 2 diabetes mellitus quantitatively and can assess the progression of atherosclerosis in patients with normal carotid artery morphology through the changes in PWV-ES values. This technique is significant for clinical diagnosis and treatment.
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Zhu Min, Li Yang, Du Xiaoying, Guo Jie, Su Lei, Cheng Li, Zhu Yinghui, Sun Yixue. Application value of the ultraphonic ultrafast pulse wave velocity technique for the quantitative evaluation of the carotid elastic changes in patients with type 2 diabetes mellitus. Chinese Journal of Anatomy and Clinics, 2020, 25(3): 232-237.
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2020, Vol. 25 
