乳腺浸润性微乳头状癌临床病理因素的研究现状

doi:10.3760/cma.j.issn.2095-7041.2014.03.021

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摘要目的探讨年龄、肿瘤大小、组织学及核分级、腋淋巴结、激素受体、生长因子受体及细胞增值率等临床病理因素在乳腺浸润性微乳头状癌(IMPC)发生、发展、转移及预后的评估中的意义。方法应用Pubmed及CNKI数据库系统以“IMPC”为关键词检索文献,筛选出相关一次文献,对文献进行分析。结果 IMPC中肿瘤大小、IMPC成分的比例、共存病灶的病理类型和组织学分级均与淋巴结转移的发生率无关;IMPC独特的形态学特征和间质淋巴细胞浸润可能是其高侵袭性的原因所在;IMPC中雌激素受体(ER)和人类表皮生长因子受体2(HER2)阳性表达比率高,其中,ER阳性表达可作为一个积极预后指标。结论对IMPC这一特殊亚型认识还比较肤浅,随着研究的不断深入,IMPC的诊治状况将得到进一步的改观。

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	柳林
	张建国

关键词 ：乳腺浸润性微乳头状癌, 临床病理因素, 研究现状

Abstract：Objective To explore the guiding significance and research status of age, tumor size, histological and nuclear grade, axillary lymph nodes, hormone receptors, growth factor receptors, cell proliferation rate and other clinicopathological factors in invasive micropapillary carcinoma of the breast(IMPC). Methods With "IMPC" as a keyword to search literatures in PubMed and CNKI database for analysis.Results There was no correlation between the incidence of nodal metastasis and the tumor size, amount of IMPC component, coexistent pathological type and histological grade. The unique morphological characteristics and interstitial lymphocytic infiltration may be the cause for its high invasiveness. There was a higher rate of estrogen receptor(ER) positivity and human epidermal growth factor receptor type 2(HER2) overexpression in invasive micropapillary carcinoma of the breast, and ER positivity is a positive prognostic factor for patients with IMPC.Conclusions Understanding of IMPC which is a special subtype is superficial, but with the deepening of the study, diagnosis and treatment of invasive micropapillary carcinoma of the breast will be further improved.

Key words： Invasive micropapillary carcinoma of the breast Clinicopathological factors research status

收稿日期: 2013-10-21

通讯作者: 张建国 E-mail: zhangjianguo27@163.com

引用本文:

柳林,张建国. 乳腺浸润性微乳头状癌临床病理因素的研究现状[J]. 中华解剖与临床杂志, 2014, 19(3): 253-256.
Liu Lin, Zhang Jianguo. Research status of clinicopathological factors in invasive micropapillary carcinoma of the breast. Chinese Journal of Anatomy and Clinics, 2014, 19(3): 253-256.

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http://www.cjac.com.cn/CN/10.3760/cma.j.issn.2095-7041.2014.03.021 或 http://www.cjac.com.cn/CN/Y2014/V19/I3/253

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