Clinical research progress of brain protection in aortic arch surgery
Zhang He1, 2, Xue Yunxing3, Wang Dongjin1, 2
1 Graduate School of Peking Union Medical College, Beijing 100730, Chinese Academy of Medical Science, Beijing 100730, China;
2 Department of Cardiac and Thoracic Surgery, Nanjing Drum Tower Hospital, Nanjing 210008 China;
3 Nanjing Medical University Drum Tower Clinical Medical College, Nanjing 210008, China
Abstract：Objective To summarize the findings of clinical studies on circulatory arrest temperature and cerebral perfusion mode in aortic arch surgery. Methods A search of English and Chinese databases, such as PubMed, SinoMed, CNKI, and Wanfang, was conducted using the keywords “aorta” “aortic arch” “brain protection” “cerebral perfusion” and “主动脉” “主动脉弓” “脑保护” “脑灌注” to obtain literature related to the circulatory arrest temperature and perfusion mode in cerebral protective measures of aortic arch surgery published from January 2000 to January 2020. After reviewing these articles on the basis of the established inclusion and exclusion criteria, a total of 42 published reports, including 3 in Chinese and 39 in English, were finally included in the analysis. Results Deep hypothermia and antegrade cerebral perfusion were the most effective brain protective measures in clinical aortic arch surgery. Many studies showed that moderate hypothermia and retrograde cerebral perfusion are equally safe and effective. Conclusions Hypothermia combined with perfusion is gradually becoming the main brain protective strategy in aortic arch surgery. However, the choice of temperature and perfusion mode requires further study.
张赫, 薛云星, 王东进. 主动脉弓部手术脑保护的临床研究现状[J]. 中华解剖与临床杂志, 2020, 25(6): 705-708.
Zhang He, Xue Yunxing, Wang Dongjin. Clinical research progress of brain protection in aortic arch surgery. Chinese Journal of Anatomy and Clinics, 2020, 25(6): 705-708.
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2020, Vol. 25 
