Volume changes of hippocampus and entorhinal cortex and their ralationship with MMSE score in Alzheimer's disease patients with different degrees of cognitive impairment
Li Jian, Qi Jinglin, Pan Weiling, Song Dongmei
Department of Medical Imaging, Zibo Hospital of the 960th Hospital of the PLA Joint Logistics Support Force, Zibo 255300, China
Abstract:Objective This study aimed to explore the changes of the volumes of hippocampus and entorhinal coreex in patients with Alzheimer's disease (AD) with different degrees of cognitive impairment ,and its correlation with the score of the mini-mental state examination(MMSE). Methods The clinical and imaging data from 86 patients with AD in Zibo Hospital of the 960th Hospital of the PLA Joint Logistics Support Force from September 2017 to September 2021 were collected for the retrospective cross-sectional study. The study included 54 males and 32 females aged 55-87 (73.9±8.1) years. According to the Clinical Dementia Rating Scale (CDR), 86 patients were divided into three groups, in which 36 patients with 0.5 CDR score were classified into the mild cognitive impairment (MCI) group, 21 patients with score of 1 were classified into the mild AD group, and 29 patients with score of 2-3 were classified into the moderate and severe AD group. The bilateral hippocampal and entorhinal cortex volumes were measured by MRI, and the MMSE score was used to evaluate the cognitive function of patients. In terms of observation indicators, clinical baseline data such as gender, age, years of education, and MMSE score were compared among the three groups. The hippocampal and entorhinal cortex volumes were compared among the three groups, and the correlation between MMSE score and volumes of hippocampus and entorhinal cortex in patients with AD was analyzed. Results (1) No statistically significant differences were observed in clinical baseline data, such as gender, age, and years of education among the three groups (all P values >0.05). Based on the comparison of MMSE score, as the groups could be ranked into MCI group>mild AD group>moderate-to-severe AD group (F=113.29, P<0.001). (2) The left and right hippocampal volumes measured by MRI were (3.24±0.32) and (3.22±0.31) cm3 in the MCI group, (2.72±0.53) and (2.84±0.56) cm3 in the mild AD group, and (2.31±0.55) and (2.46±0.54) cm3 in the moderate-to-severe AD group. The volumes of the left and right entorhinal cortex were (1.42±0.26) and (1.39±0.27) cm3 in MCI group, (1.28±0.24) and (1.24±0.25) cm3 in the mild AD group, and (1.04±0.31) and (1.06±0.34) cm3 in the moderate-to-severe AD group. Based on the MRI measurement of left and right hippocampal volumes and entorhinal cortex volumes, the three groups could be ranked as MCI group>mild AD group>moderate-to-severe AD group (all P<0.05). (3) The MMSE score in 86 patients with AD was 10-27 (20.90±5.23) points, and the score was positively correlated with left and right hippocampal volumes and entorhinal cortex volumes measured by MRI (r=0.82, 0.81, 0.73, 0.72, all P values <0.001). Conclusion With the increasing degree of cognitive impairment, the volumes of hippocampus and entorhinal cortex measured by MRI gradually decrease among AD patients, and MMSE score is correlated with the volumes of hippocampus and entorhinal cortex.
李健, 齐景林, 潘为领, 宋冬梅. 不同认知功能障碍程度阿尔茨海默病患者海马、内嗅皮层体积变化及其与MMSE评分的关系[J]. 中华解剖与临床杂志, 2023, 28(3): 159-164.
Li Jian, Qi Jinglin, Pan Weiling, Song Dongmei. Volume changes of hippocampus and entorhinal cortex and their ralationship with MMSE score in Alzheimer's disease patients with different degrees of cognitive impairment. Chinese Journal of Anatomy and Clinics, 2023, 28(3): 159-164.
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