基于产前3.0 T MRI true FISP序列胎儿腰椎发育与孕周关系的影像学观察

doi:10.3760/cma.j.cn101202-20230519-00132

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1597 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨孕中晚期宫内胎儿腰椎3.0 T MRI真稳态进动梯度回波序列（true FISP）矢状位二维定量指标与孕周的关系。方法横断面研究。纳入2020年1月—2023年4月青岛大学附属泰安市中心医院行产前MRI检查的59例胎儿的影像资料。孕妇年龄19~41（29.8±5.1）岁,孕周26⁺¹~39⁺²（32.7±3.7）周。采用3.0 T MR扫描仪对胎儿行MRI检查,采集true FISP图像。在true FISP图像上测量腰椎长轴矢状位二维定量指标（腰椎总长度,L₁、L₃椎体骨化中心的上下径、前后径）。分析胎儿腰椎二维定量指标与孕周的相关性,并应用线性回归分析获得相应的腰椎生长动力学回归方程。结果 59例胎儿腰椎总长度及L₁和L₃椎体骨化中心的上下径、前后径与孕周均呈正相关,差异均有统计学意义（r=0.79~0.95,P值均<0.001）。胎儿腰椎总长度及L₁和L₃椎体骨化中心的上下径、前后径均随孕周增加呈线性增长,线性回归方程：Ŷ_{腰椎总长度}=-0.153+0.141 X_孕周（R²=0.90,P<0.001）,Ŷ_L1上下径=-0.226+0.023 X_孕周（R²=0.77,P<0.001）, Ŷ_L3上下径=-0.264+0.025 X_孕周（R²=0.80,P<0.001）,Ŷ_L1前后径=-0.284+0.029 X_孕周（R²=0.63,P<0.001）, Ŷ_L3前后径=-0.274+0.030 X_孕周（R²=0.63,P<0.001）。结论孕中晚期胎儿腰椎3.0 T MRI true FISP序列矢状位二维定量指标与孕周均呈正相关,生长动力学特征符合线性回归模型,可为产前评估胎儿的腰椎发育情况提供参考。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	张辉
	康琦
	尚华
	马得廷

关键词 ：胎儿发育, 腰椎, 磁共振成像, 真稳态进动梯度回波序列, 产前检查

Abstract：Objective To explore the relationship between the 2D quantitative measurements of the sagittal lumbar spine and gestational age (GA) during middle and late fetal pregnancy on the basis of true fast imaging with steady-state precession (FISP) images of 3.0 T magnetic resonance imaging (MRI). Methods The cross-sectional study was conducted. This study used the imaging data of 59 pregnant women who underwent MRI examinations at the Affiliated Taian City Central Hospital of Qingdao University from January 2020 to April 2023. The women were aged 19-41 (29.8±5.1) years, and GA was 26⁺¹-39⁺² (32.7±3.7) weeks. The fetus was examined using a 3.0 T magnetic resonance scanner, and true FISP images were collected. The 2D sagittal position with the long axis of the lumbar spine on the true FISP images was measured (total length of lumbar spine, the superior-inferior and anteroposterior diameters of the ossification centers of the L₁ and L₃vertebrae). The correlation between the 2D quantitative indexes of the fetal lumbar spine measurement index and GA was analyzed, and linear regression analysis was performed to obtain the corresponding regression equation for the growth kinetics of the lumbar spine. Results Among the 59 cases, a positive correlation was observed between GA and the length of the fetal lumbar spine and the superior-inferior and anteroposterior diameters of the ossification centers of the L₁ and L₃ vertebrae. The differences were statistically significant (r = 0.79-0.95, all P values < 0.001). The length of the fetal lumbar spine and the superior-inferior and anteroposterior diameters of the ossification centers of the L₁ and L₃ vertebrae exhibited linear growth with increasing GA. The linear regression equations were as follows: Ŷ_{total length of lumbar spine} = -0.153 + 0.141 X_GA, (R² = 0.90, P < 0.001); Ŷ_{superior-inferior diameters of L1}=-0.226 + 0.023 X_GA, (R² = 0.77, P < 0.001); Ŷ_{superior-inferior diameters of L3}= -0.264 + 0.025 X_GA, (R² = 0.80, P < 0.001); Ŷ_{oposterior diameters of L1}= -0.284 + 0.029 X_GA, (R² = 0.63, P < 0.001); and Ŷ_{anteroposterior diameters of L3}= -0.274 + 0.030 X_GA, (R² = 0.63, P < 0.001). Conclusion On the basis of 3.0 T true FISP MRI, the 2D quantitative measurements on the sagittal lumbar spine are positively correlated with GA during middle and late fetal pregnancy. The growth dynamics characteristics fit a linear regression model, which can provide reference for the prenatal assessment of fetal lumbar spine development.

Key words： Fetal development Lumbar spine Magnetic resonance imaging True fast imaging with steady-state precession Prenatal examination

收稿日期: 2023-05-19

通讯作者: 马得廷, Email: medimage@163.com

引用本文:

张辉, 康琦, 尚华, 马得廷. 基于产前3.0 T MRI true FISP序列胎儿腰椎发育与孕周关系的影像学观察[J]. 中华解剖与临床杂志, 2024, 29(2): 83-87.
Zhang Hui, Kang Qi, Shang Hua, Ma Deting. Imaging observation of the relationship between fetal lumbar spine development and gestational age based on prenatal 3.0 T MRI true FISP sequence. Chinese Journal of Anatomy and Clinics, 2024, 29(2): 83-87.

链接本文:

http://www.cjac.com.cn/CN/10.3760/cma.j.cn101202-20230519-00132 或 http://www.cjac.com.cn/CN/Y2024/V29/I2/83

[1]	Ulla M, Aiello H, Cobos MP, et al.Prenatal diagnosis of skeletal dysplasias: contribution of three-dimensional computed tomography[J]. Fetal Diagn Ther, 2011,29(3):238-247. DOI: 10.1159/000322212.
[2]	Goldstein I, Makhoul IR, Weissman A, et al.Hemivertebra: prenatal diagnosis, incidence and characteristics[J]. Fetal Diagn Ther, 2005,20(2):121-126. DOI: 10.1159/000082435.
[3]	张迎华, 王光彬, 马玉香. 超声与磁共振成像诊断胎儿脊柱与脊髓发育异常的对照研究[J].中华妇产科杂志, 2010, 45(3): 174-178. DOI: 10.3760/cma.j.issn.0529-567x.2010.03.004.Zhang YH, Wang GB, Ma YX.Comparative study on diagnosis of fetal dysplasia of spine and spinal cord between B ultrasonography and magnetic resonance imaging[J]. Chinese Journal of Obstetrics and Gynecology, 2010, 45(3): 174-178. DOI: 10.3760/cma.j.issn.0529-567x.2010.03.004.
[4]	Jian N, Tian MM, Xiao LX, et al.Normal development of sacrococcygeal centrum ossification centers in the fetal spine: a postmortem magnetic resonance imaging study[J]. Neuroradiology, 2018, 60(8): 821-833. DOI: 10.1007/s00234-018-2050-0.
[5]	Szpinda M, Baumgart M, Szpinda A, et al.Cross-sectional study of the ossification center of the C1-S5 vertebral bodies[J]. Surg Radiol Anat, 2013, 35(5): 395-402. DOI: 10.1007/s00276-012-1045-5.
[6]	康琦,罗晓瑜,马得廷. 基于3.0 T MRI的二维定量指标在胎儿肱骨发育评估中的应用价值[J]. 中华解剖与临床杂志, 2022, 27(11): 753-757. DOI:10.3760/cma.j.cn101202-20220209-00038.Kang Q, Luo XY, Ma DT.Value of two-dimensional quantification based on 3.0 T magnetic resonance imaging in the assessment of fetal humeral development[J]. Chin J Anat Clin, 2022, 27(11): 753-757. DOI:10.3760/cma.j.cn101202-20220209-00038.
[7]	马得廷,崔红,李秀娟,等. 3.0 T MR TrueFISP序列负间隔扫描经多平面重组显示胎儿股骨长轴的可行性研究[J]. 临床放射学杂志, 2022, 41(3): 562-566. DOI:10.13437/j.cnki.jcr.2022.03.006.Ma DT, Cui H, Li XJ, et al.Feasibility study of multiplane reformation to show the long axis of femur after negative interval scanning with 3.0 T MR TrueFISP sequence[J]. Journal of clinical radiology, 2022, 41(3): 562-566. DOI:10.13437/j.cnki.jcr.2022.03.006.
[8]	赵慧,林祥涛,徐艳霞,等. 胎儿腰椎长度发育与孕龄及性别相关性3.0T 磁共振研究[J]. 医学影像学杂志, 2015, 25(2): 330-333,336.Zhao H, Lin XT, Xu YX, et al.Study on correlation between the fetal lumbar spine length and gestational age and sexual dimorphisms by 3.0T MR[J]. J Med Imaging, 2015, 25(2) :330-333,336.
[9]	严祥虎,包雨微,方纪成,等. 3.0 T磁共振True FISP及HASTE序列胎儿椎体成像对比[J].放射学实践, 2020,35(6):768-772. DOI:10.13609/j.cnki.1000-0313.2020.06.014.Yan XH, Bao YW, Fang JC, et al.Comparative study of TrueFISP and HASTE sequences in fetal vertebra imaging on 3.0T magnetic resonance[J]. Radiol Practice, 2020, 35(6): 768-772. DOI: 10.13609/j.cnki.1000-0313.2020.06.014.
[10]	Widjaja E, Whitby EH, Paley MNJ, et al.Normal fetal lumbar spine on postmortem MR imaging[J]. AJNR Am J Neuroradiol, 2006, 27(3): 553-559.
[11]	Schild RL, Wallny T, Fimmers R, et al.Fetal lumbar spine volumetry by three-dimensional ultrasound[J]. Ultrasound Obstet Gynecol, 1999,13(5):335-339. DOI: 10.1046/j.1469-0705.1999.13050335.x.
[12]	Schild RL, Wallny T, Fimmers R, et al.The size of the fetal thoracolumbar spine: a three-dimensional ultrasound study[J]. Ultrasound Obstet Gynecol, 2000,16(5):468-472. DOI: 10.1046/j.1469-0705.2000.00256.x.
[13]	Vignolo M, Ginocchio G, Parodi A, et al.Fetal spine ossification: the gender and individual differences illustrated by ultrasonography[J]. Ultrasound Med Biol, 2005,31(6):733-738. DOI: 10.1016/j.ultrasmedbio.2005.02.013.
[14]	Szpinda M, Baumgart M, Szpinda A, et al.Morphometric study of the T6 vertebra and its three ossification centers in the human fetus[J]. Surg Radiol Anat, 2013,35(10):901-916. DOI: 10.1007/s00276-013-1107-3.
[15]	程亚旎, 赵鹏, 杨涛, 等. 孕中晚期宫内胎儿T12椎体生长发育的MRI研究[J].医学影像学杂志,2023,33(2):300-304.Ceng YN, Zhao P, Yang T, et al.The development of intrauterine fetal thoracic spine in the second and third trimester of pregnancy through MRI study[J]. J Med Imaging, 2023, 33(2):300-304.
[16]	Shih SL, Lee YJ, Huang FY, et al.Radiological evaluation of bone growth in neonates born at gestational ages between 26 and 41 weeks: cross-sectional study[J]. Early Hum Dev, 2005, 81(8): 683-688. DOI: 10.1016/j.earlhumdev.2005.04.001.
[17]	Bagnall KM, Harris PF, Jones PR.A radiographic study of the human fetal spine[J]. Journal of anatomy, 1979, 128(4): 777. DOI:10.1002/ar.1092080213.