Meta-analysis of changes in choroidal thickness in migraine by using optical coherence tomography
Liu Baijing1, Wang Wei2, Zeng Xiaohua1
1Department of Pain, the 1st Affiliated People's Hospital of Chenzhou City, Nanhua University, Chenzhou 423000, China; 2Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China
Abstract：Objective This study aims to systematically determine changes in choroidal thickness in patients with migraines.Methods Studies that evaluated choroidal thickness in patients with migraine by optical coherence tomography were identified by searching Pubmed, Embase, Scopus, China Biomedical Literature Database (CBM), CNKI, VIP, and Wan Fang databases. Two investigators independently screened, extracted, and evaluated the included studies. A meta-analysis was performed using Stata 14.0 software.Results A total of 12 case-control studies with 1091 subjects were eligible, including 646 patients in the migraine group and 646 individuals in the control group. The meta-analysis showed that the choroidal thickness at all points was significantly reduced in the migraine group, with the mean difference and 95% confidential interval (95% CI) of -39.97 μm (-54.43--25.50) for subfoveal choroidal thickness, -41.60 μm (-57.74--25.45) for choroidal thickness at nasal 1.0 mm, -41.95 μm (-59.59--24.31) for choroidal thickness at nasal 2.0 mm, -44.32 μm (-63.31--25.34) for choroidal thickness at temporal 1.0 mm, and -39.51 μm (-59.25--19.77) for choroidal thickness at temporal 2.0 mm. The measurements of choroidal thickness were not significantly different between patients with migraine with and without aura.Conclusions Patients with migraine have thinner choroidal thickness. Choroidal thickness may be the ocular biomarker and useful for diagnosis of migraine. Further studies are needed to clarify the altered choroidal thickness in different types of migraine.
刘柏京, 王伟, 曾小华. 偏头痛患者脉络膜厚度改变的系统评价[J]. 中华解剖与临床杂志, 2020, 25(5): 520-526.
Liu Baijing, Wang Wei, Zeng Xiaohua. Meta-analysis of changes in choroidal thickness in migraine by using optical coherence tomography. Chinese Journal of Anatomy and Clinics, 2020, 25(5): 520-526.
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2020, Vol. 25 
