Quantitative CT study of volumetric bone mineral density of cervical vertebrae and lumbar vertebrae in healthy Chinese
Zhang Yong1, Cheng Xiaoguang2, Tian Wei3, Wu Cheng'ai4, Li Hui1, Wang Jianfeng1, Zhou Chuanguo1, Gao Kun1
1Department of Interventional Radiology, Beijing Chao-Yang Hospital, Capital Medical University,Beijing 100020, China; 2Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China; 3Department of Spine Surgery, Beijing Jishuitan Hospital,Beijing 100035, China; 4Beijing Institute of Traumatology and Orthopedics, Beijing 100035, China
Abstract:Objective To investigate the distribution of volumetric bone density (vBMD) of cervical vertebrae and lumbar vertebrae in adult healthy Chinese.Methods A cross-sectional study method was used. From December 2014 to January 2016, 770 healthy volunteers were recruited in Beijing Jishuitan Hospital, including 329 males and 441 females, aged 21-59 years. Volunteers were divided into 4 groups according to age: 142 people in group A (21-30 years old); 262 people in group B (31-40 years old); 263 people in group C (41-50 years old); 103 people in group D (51-60 years old). Quantitative CT scans of cervical and lumbar spine were performed on volunteers using a Japanese TOSHIBA 128-row CT machine, and the vBMD of C2-C7, L2-L4 were measured using Mindways bone density measurement software. In males and females, one-way analysis of variance was used to compare the differences of vBMD of the same vertebrae between different age groups, and between different vertebrae in the same age group, and to observe the distribution of vBMD in cervical and lumbar vertebrae in different genders, different age groups and different segments. Correlation analysis was conducted between the vBMD of different vertebrae in males and females, and the correlation degree of vBMD of each vertebrae was observed.Results In all male volunteers, the average vBMD values of the C2-C7 and L2-L4 vertebrae were (288.40±60.63), (275.71±56.33), (283.91±59.62), (278.95±53.76), (253.38±49.99), (217.94±44.96), (151.64±31.74), (145.22±31.77) and (147.16±35.81)mg/cm3, respectively. In all female volunteers, the average vBMD values of the C2-C7, L2-L4 vertebrae were (329.24±74.34), (313.88±67.86), (328.54±73.40), (323.22±72.53), (286.44±66.36)、(251.53±58.63), (168.50±37.10), (160.78±37.00) and (162.81±37.10)mg/cm3, respectively. Both males and females, the vBMD values of the cervical and lumbar vertebrae decreased with age,the differences were statistically significant (all P values<0.05). Among male volunteers, vBMD of C2-C7 vertebrae in the same age group showed a decreasing trend, and the difference was statistically significant (all P values<0.05). There was no significant difference in vBMD of the L2-L4 vertebrae (all P values>0.05). Among female volunteers, vBMD of C2-C7 vertebrae in the same age group showed a decreasing trend, and the difference was statistically significant (all P values<0.05). The vBMD of the L2-L4 vertebral showed a decreasing trend only in D group (P<0.05), while no significant difference in vBMD of other age groups (all P values>0.05). In both male and female volunteers, the vBMD values of cervical spine were more than 200 mg/cm3, lumbar spine was less than 200 mg/cm3, and cervical spine was higher than lumbar spine in any age group(all P values<0.01). There was significant correlation between vBMD values of different vertebrae in male and female(rmale=0.509-0.968, rfemale=0.658-0.976, all P values<0.01). In males, rintercervical=0.667-0.928, rinterlumbar=0.850-0.968, rcervical and lumbar =0.509-0.675. In females, rintercervical=0.754-0.933, rinterlumbar=0.956-0.973, rcervical and lumbar=0.658-0.752. The correlation coefficients of vBMD of intercervical and interlumbar were higher than those between cervical vertebra and lumbar vertebra.Conclusions The vBMD values of cervical and lumbar vertebrae are different in different genders, different age groups and different segments, but there are moderate to strong correlations between vBMD values of vertebrae. The results can provide reference data for clinical monitoring of osteoporosis and risk assessment of fracture.
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Zhang Yong, Cheng Xiaoguang, Tian Wei, Wu Cheng'ai, Li Hui, Wang Jianfeng, Zhou Chuanguo, Gao Kun. Quantitative CT study of volumetric bone mineral density of cervical vertebrae and lumbar vertebrae in healthy Chinese. Chinese Journal of Anatomy and Clinics, 2020, 25(1): 1-7.
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