Timing of iliac vein stenting in acute lower extremity deep vein thrombosis with severe stenosis of the iliac vein thrombectomy
Zhou Wenjie1,2, Yang Chao1, Wang Xiaoyun1, Zhu Xiaoli1, Lyu Penghua2, Duan Pengfei1
1Department of Interventional Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215000, China; 2Department of Interventional Radiology, Northern Jiangsu People's Hospital, Yangzhou 225000, China
Abstract:Objective This study aimed to investigate the timing of iliac vein stenting during thrombectomy for acute lower extremity deep vein thrombosis (DVT) with severe iliac vein stenosis. Methods A total of 68 patients with acute lower extremity DVT and severe iliac vein stenosis who underwent surgery in the First Affiliated Hospital of Soochow University from January 2020, to December 2021, were enrolled, including 24 males and 44 females aged 27-87 (62.6±11.6) years. All patients received AngioJet thrombectomy and iliac vein stent placement. The patients were divided into groups in accordance with the period of stent placement: 35 cases received AngioJet thrombectomy and catheter-directed thrombolysis after iliac vein stenting during the same period (the concurrent group), and 33 cases received AngioJet thrombectomy followed by catheter-directed thrombolysis and iliac vein stenting during the staged period (the staged group). Observation indices: (1) The baseline data, such as age, gender, side of the affected limb, combined pulmonary embolism, thrombus type, disease duration, preoperative limb circumference difference and recent surgery/trauma, malignant tumor, and autoimmune disease of the two groups were compared. (2) The dose of thrombolytic agent, thrombolytic time, thrombus clearance rate, hospital stay, and occurrence of complications during the treatment period of the two groups were compared. (3) The cumulative stent patency rate, limb circumference difference, and incidence of post-thrombotic syndrome (PTS) and venous clinical severity score (VCSS) in the two groups at 12 months after the procedure were compared. Results (1) The difference between the baseline data of the two groups was not statistically significant (all P values >0.05). (2) The procedure was technically successful in all 68 patients. The urokinase dosage, thrombolysis time, and hospital stay during treatment were (0.857±0.320) ×106 units, (3.3±1.6) days, and (6.7±1.7) days, respectively, in the concurrent group, and (1.176±0.198)×106 units, (4.9±1.0) days, and (8.6±2.0) days, respectively, in the staged group. The differences were statistically significant (t=-4.96, -4.95, -4.03; all P values <0.001). The differences in AngioJet aspiration time and thrombus clearance rate between the two groups were not statistically significant (all P values >0.05). The complication rates of patients in the concurrent group and the staged group were 45.7% (16/35) and 51.5% (17/33), respectively, and the difference was not statistically significant (χ2=0.23, P=0.632). All patients did not suffer from bleeding, symptomatic pulmonary embolism, and other serious complications. (3) All 68 patients were followed up for 12-24(17.3±3.5) months after the procedure. At 12 months after the procedure, the cumulative patency rate of stent, limb circumference difference, PTS incidence, and VCSS score of the two groups were compared, and the differences were not statistically significant (all P values >0.05). Conclusion For patients with acute lower limb DVT combined with severe stenosis of the iliac vein, either contemporaneous or staged iliac vein stenting can be an option, and the two groups have similar risks and near- and mid-term efficacy. Patients undergoing simultaneous stent implantation use less thrombolytic drugs and have shorter hospital stay than patients undergoing staged stent implantation.
周文杰, 杨超, 王孝运, 朱晓黎, 吕朋华, 段鹏飞. 急性下肢深静脉血栓形成伴髂静脉重度狭窄血栓清除术中髂静脉支架置入时机的选择[J]. 中华解剖与临床杂志, 2024, 29(4): 222-227.
Zhou Wenjie, Yang Chao, Wang Xiaoyun, Zhu Xiaoli, Lyu Penghua, Duan Pengfei. Timing of iliac vein stenting in acute lower extremity deep vein thrombosis with severe stenosis of the iliac vein thrombectomy. Chinese Journal of Anatomy and Clinics, 2024, 29(4): 222-227.
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