Abstract：Objective:To investigate the clinical effects an safety degree of high positive end-expiratory pressure(PEEP)combined with low tidal volume in patients with acute respiratory distress syndrome. Methods:Thirty patients with ARDS admitted from May 2009 to Jun 2011 in intensive care unit of our hospital wereenrolled in study. High PEEP plus low tidal volume(6ml/kg)and other symptomatic treatment were adopted.Results:30 patients with arterial partial pressure of oxygen(PaO2)and oxygenation index(PaO2/FiO2)were significantly improved and the 2nd～5th day was the most obvious improvement in arterial partial pressure of oxygen(PaO2), the most obvious improvement of oxygenation index(PaO2/FiO2)occurred on the 4th ～5th day. No barotrauma occurred, no arrhythmias, no significant changes in heart rate and mean arterial pressure. Central venous pressure with positive end-expiratory pressure increased and the high side, but had no significant effect on mean arterial pressure.Conclusions:The high PEEP plus low tidal volume can increase alveolar gas exchange, improve oxygenation and reduce ventilator-associated lung injury.
2013, Vol. 18 
