Therapeutic comparison of bladder instillation with hydroxycamptothecine and pirarubicin on preventing the postoperative recurrence of superficial bladder cancer
Guan Han*, Li Qingwen
* Master of Grade of 2011 of Surgery, Benbu Medical College, Anhui 233030, China
Abstract：Objective Toevaluate the effects of bladder instillation with hydroxycamptothecine and pirarubicin on preventing the postoperative recurrence of superficial bladder cancer.Methods From December 2010 to December 2011, 80 patients of postoperative superficial bladder cancer were selected in the First Affiliated Hospital of Bengbu Medical College. According to random number table, to patients were divided into two groups: pirarubicin group(40) and hydroxycamptothecine group(40), different drugs were used, the occurrence and adverse reactions at 3, 6, 12, 24 months after treatment were closely observed.Results All patients were followed up for 24 months, the recurrence rate of hydroxycamptothecine and pirarubicin group were 15.0%(6/40) and 17.5%(7/40), the diference was not statistically significant(χ2=0.092, P>0.05). The incidence rate of adverse reactions in hydroxycamptothecine and pirarubicin group were 27.5%(11/40) and 17.5%(7/40), the difference was not statistically significant(χ2=1.147, P>0.05).Conclusions The effects of bladder instillation with hydroxycamptothecine and pirarubicin on preventing the postoperative recurrence of superficial bladder cancer are similar.These two drugs can be used as the promising drug for bladder instillation.
关翰, 李庆文. 吡柔比星与羟基喜树碱膀胱灌注预防表浅性膀胱癌术后复发的疗效对比[J]. 中华解剖与临床杂志, 2015, 20(1): 64-66.
Guan Han, Li Qingwen. Therapeutic comparison of bladder instillation with hydroxycamptothecine and pirarubicin on preventing the postoperative recurrence of superficial bladder cancer. Chinese Journal of Anatomy and Clinics, 2015, 20(1): 64-66.
Vicente-Rodriguez J, Chéchile G, Algaba F, et al. Value of random endoscopic biopsy in the diagnosis of bladder carcinoma in situ[J]. Eur Urol, 1987, 13(3): 150-152.
[2]
那彦群. 中国泌尿外科疾病诊断治疗指南[M]. 北京: 人民卫生出版社, 2011: 29-47.
[3]
Siegel R, Naishadham D, Jemal A. Cancer statistics for Hispanics/Latinos, 2012[J]. CA Cancer J Clin, 2012, 62 (5): 283-298.
Takahashi T, Kushiro A, Nomoto K, et al. Antitumor effects of the intravesical instillation of heat killed cells of the Lactobacillus casei strain Shirota on the murine orthotopic bladder tumor MBT-2[J]. J Urol, 2001, 166(6): 2506-2511.
[10]
Kawamura S, Fujioka T, Kubo T, et al. A course of pirarubicin vesical irrigation at thirty mg effectively prevents post-TUR recurrence of superficial bladder cancer[J]. Gan To Kagaku Ryoho, 1996, 23(4): 465-470.
2015, Vol. 20 
