Abstract：Objective This study aims to summarize the latest progress of endogenous regeneration and repair in musculoskeletal system and its possible mechanism. Methods Literature on the study of endogenous regeneration and repair in bone, cartilage, intervertebral disc, and muscle (tendon) published before September 2023 was searched in NCBI, Web of Science, CNKI, and Wanfang databases, and 348 studies were retrieved. According to inclusion and exclusion criteria, 49 studies were finally included and used to analyze the possible mechanism of endogenous regeneration and repair in the musculoskeletal system. Results Endogenous regeneration and repair was conducted in bone, cartilage, intervertebral disc, muscles, and tendon to promote the regeneration and repair of related tissues by introducing relevant biological signals (such as homing signals, etc.) or single bioengineering scaffold. The mechanism of endogenous regeneration and repair may involve the expression of receptors and adhesion molecules, the interaction with endothelial cells, and the induction of the immune system. Conclusion The research of endogenous regeneration and repair in the musculoskeletal system has made great progress. Promoting endogenous regeneration and repair of tissues is a promising method in regenerative medicine and has a broad prospect in clinical application in the future.
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2023, Vol. 28 
