Abstract：Objective To investigate the correlation between homocysteine (Hcy) and inflammatory bowel disease (IBD)-related thrombotic diseases, and to provide a reference with regard to further studies of IBD-related thrombotic disease.Methods The related literatures in the PubMeb, Medline, EMbase, CNKI and CBM databases were systematically reviewed from January 1993 to December 2013 in order to elucidate any potential association between Hcy and IBD-related thrombotic diseases.Results Patients with IBD have an increasing risk of thrombosis because of repeated inflammatory activity and the hypercoagulable state. Hyperhomocysteinemia (HHcy) is involved in the pathophysiological process of IBD-related thrombotic diseases. Oxidative damage to endothelium and imbalance in the body of anticoagulant system can be the major contributing factors to IBD-related thrombotic diseases. HHcy is an independent risk factor of thrombosis.Conclusions The present data indicate that Hcy plays a role in the complex pathogenesis in patients with IBD, affected by multiple factors. Similarly, Hcy plays an important role in IBD-related thrombotic diseases, which needs further study to clarify the definite mechanism of patients with IBD.
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Zhang Shuang, Zhang Xu, Mei Qiao. Research progress on homocysteine and inflammatory bowel disease-related thrombotic disease. Chinese Journal of Anatomy and Clinics, 2014, 19(5): 434-436.
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2014, Vol. 19 
