Abstract：Objective To review the research and progress of treating intervertebral disc degeneration (IDD) by using BMSCs transplantation, and provide theoretical basis for further basic researches.Methods CNKI database and ISI Web of Knowledge database from 2000 to 2014 were retrieved by the first author with the key words of "bone marrow mesenchymal stem cells (BMSCs), cell therapy, intervertebral disc degeneration (IDD)" in Chinese and in English, respectively. The biological characteristics and cultivation of BMSCs, the influence factors of BMSCs differentiate into intervertebral disc cells and cell therapy for IDD by BMSCs transplantation in vivo were summarized.Results We can obtain enough amount of BMSCs. BMSCs has low immunogenicity and good differentiation potential, and these make BMSCs a very good seed cell source for cell therapy of IDD. Under the condition of improving the micro environment of IDD, or a special support material system for cell cultivation, or the induction of cytokines, or co-cultured with intervertebral disc cell, BMSCs can differentiate into nucleus pulposus cells, express proteoglycan and collagen-Ⅱ. Whether autograft or allograft, even heterogeneous, BMSCs can survive and propagate in degenerative intervertebral disc for long-term, promote the secretion of intervertebral disc cells matrix.Conclusions As the study of BMSCs and cellular therapy, a lot of work has been done on treating IDD by using BMSCs transplantation and we have made some achievements. Although using BMSCs transplantation in the treatment of IDD also shows huge application prospect, there are still many problems need to be solved before applying it in clinical treatment.
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2015, Vol. 20 
