Abstract：Objective To explore the progress of submucosal injection solutions for endoscopic submucosal dissection(ESD).Methods The literatures about submucosal injection at home and abroad from January 2008 to January 2014 were seached in WANFANG PubMed and Web of science database by using "ESD, Submucosal injection" as key words.Results The greatest problem with 0.9% NS solution is that it rapidly dissipates into the surrounding tissue. Hypertonic solution has a clear injury of mucosal tissues. Hyaluronic acid has maintained long time submucosa liquid pad and security, so it can be used as a model submucosal injection solution. As a synthesized product, Hydroxymethyl cellulose may cause antigen-antibody reaction, and Fibrinogen mixture has a risk of spread of hepatitis and other viruses. Carbon dioxide as a submucosal injection has a better mucosal lifting time than saline. Alginate can be used as an alternative to hyaluronic acid. Elastic polymer IDEEp submucosa lifting height is better than that of normal saline, and it can effectively promote the healing of mucosa after ESD. Photo-crosslinked chitosan hydrogel has a stronger ability to maintain mucosa lift than sodium hyaluronate, but the degradable time is too long, which delayed the healing of mucosa.Conclusions These submucosal agents differ with regard to their efficacy, cost, and availability. The traditional media of submucosal injection of the existence of deficiencies, and the new media of submucosal injection have a comparative advantage, but cannot fully meet the needs of the ESD. In order to make ESD technology more secure and efficient,we need to find a suitable ESD submucosal injection.
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2015, Vol. 20 
