The value of diffusion kurtosis imaging in predicting UGT1A1 * 28 gene mutation in rectal adenocarcinoma
Yang Dongyu1, Cui Yanfen2, Yang Xiaotang2
1Department of Medical Imaging, Shanxi Medical University, Taiyuan 030000, China; 2Department of Radiology, Shanxi Province Tumor Hospital, Taiyuan 030000, China
Abstract:Objective To evaluate the predictive value of diffusion kurtosis imaging (DKI) in predicting uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) *28 gene mutation in rectal adenocarcinoma. Methods The clinical data of 167 patients with rectal adenocarcinoma confirmed by pathology in Shanxi Province Tumor Hospital from November 2016 to August 2020 were retrospectively analyzed among 98 males and 69 females, with median aged of 62 (29–89) years. All patients underwent routine magnetic resonance imaging (MRI) sequence and DKI sequence examinations before operation. The DKI images were imported into Matlab software and the region of interest (ROI) of the tumor was delineated. The corresponding mean diffusivity (MD), mean kurtosis (MK), and apparent diffusion coefficient (ADC) were then generated. According to the results of UGT1A1*28 gene polymorphism, the patients were divided into wild and mutant type groups. Independent sample t-test was used to compare the differences of MD, MK, and ADC between two groups. The parameters with statistically significant differences were used as predictors, and receiver operating characteristic (ROC) curve and Delong test were used to evaluate the diagnostic efficacy of UGT1A1*28 gene mutation in rectal adenocarcinoma. Results Among the 167 patients with rectal adenocarcinoma, 130 cases (77.8%) were UGT1A1*28 wild type (TA6/6), while the other 37 cases were mutated. Of which 34 cases (20.4%) were heterozygous (TA6/7) and 3 cases (1.8%) were homozygous (TA7/7). MD and ADC values of wild-type group were significantly higher than those of mutant group, while MK value was significantly lower than that of mutant group, (all P values < 0.01). According to ROC curve analysis, the AUC of MD, MK, and ADC values for UGT1A1 * 28 gene mutation were 0.747, 0.836, 0.723, respectively. The corresponding sensitivity and specificity of them were 83.8% and 57.7%, 78.4% and 81.5%, 75.7% and 65.4%, respectively. Conclusion DKI parameters (MD and MK) and ADC values can be used to predict the mutation status of UGT1A1*28 gene in rectal adenocarcinoma.
杨东宇, 崔艳芬, 杨晓棠. 弥散峰度成像预测直肠腺癌UGT1A1*28基因突变的价值[J]. 中华解剖与临床杂志, 2022, 27(2): 82-86.
Yang Dongyu, Cui Yanfen, Yang Xiaotang. The value of diffusion kurtosis imaging in predicting UGT1A1 * 28 gene mutation in rectal adenocarcinoma. Chinese Journal of Anatomy and Clinics, 2022, 27(2): 82-86.
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