Progress on the surgical treatment of limb spasmolysis, orthopedic surgery, and functional reconstruction in patients with cerebral palsy
Ning Bo1, Zhang Hailong1, Zhi Jianwen1, Wang Pohao1, Yang Han1, Zhang Shaocheng2
1Department of Neurosurgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, 510220, China; 2Department of Orthopedics, Shanghai Changhai Hospital, the First Affiliated Hospital of Naval Military Medical University, Shanghai 200433, China
Abstract:Objective To summarize the research progress on the surgical treatment of cerebral palsy with spasmolysis, orthopedic surgery, and functional reconstruction. Methods Relevant literatures on the diagnosis and treatment of cerebral palsy that were published from January 2000 to June 2021 in CNKI, Wanfang Data, PubMed, and other Chinese and English databases were searched. Forty-seven literatures were finally included to summarize and analyze the data from three aspects, namely, the spasmolysis, orthopedic surgery, and functional reconstruction of cerebral palsy, literatures with inaccessible full text, inconsistent content, redundant topics, and low quality were excluded. Results Current surgical methods for the treatment of cerebral palsy include spasmolytic surgery and orthopedic surgery. (1) Spasmolytic surgery includes selective posterior rhizotomy (SPR) and selective peripheral neurotomy (SPN). SPR could widely reduce limb muscle tension and is more suitable for tetanic limb spasm than SPN. In comparison, SPN is suitable for focal spasm because of its precision and small trauma effect in reducing single muscle tension in a muscle group. (2) Orthopaedic surgery can adjust muscle tension; release spasm; and relieve or correct deformities by tendon transfer, lengthening, or shortening (including Achilles tendon lengthening, hamstring release, posterior tibial muscle lengthening, anterior tibial muscle transposition, and adductor amputation). Orthopedic surgery is used as an important supplement to spasmolysis, and patients with cerebral palsy often need to receive SPR/SPN to relieve spasm before orthopedic surgery. (3) Limb function reconstruction surgery, which involves modified peripheral nerve transposition, includes nerve transfer graft surgery, vascularized intercostal nerve transfer, and side-to-side suture interfascicular of peripheral nerves. Conclusion The surgical treatment of cerebral palsy is very important. Individualized and staged surgical plan, combined with the application of limb spasmolysis, orthosis, and modified nerve transposition, plays a positive role in alleviating limb spasm, correcting malformation, and rebuilding limb function after central nervous system injury.
宁波, 张海龙, 植剑文, 王泊浩, 杨寒, 张少成. 脑性瘫痪患者肢体解痉、矫形与功能重建的手术治疗研究进展[J]. 中华解剖与临床杂志, 2022, 27(8): 596-600.
Ning Bo, Zhang Hailong, Zhi Jianwen, Wang Pohao, Yang Han, Zhang Shaocheng. Progress on the surgical treatment of limb spasmolysis, orthopedic surgery, and functional reconstruction in patients with cerebral palsy. Chinese Journal of Anatomy and Clinics, 2022, 27(8): 596-600.
Sangari S, Perez MA.Imbalanced corticospinal and reticulospinal contributions to spasticity in humans with spinal cord injury[J]. J Neurosci, 2019,39(40):7872-7881. DOI: 10.1523/JNEUROSCI.1106-19.2019.
[2]
Gharbaoui I, Kania K, Cole P.Spastic paralysis of the elbow and forearm[J]. Semin Plast Surg, 2016,30(1):39-44. DOI: 10.1055/s-0035-1571255.
[3]
Rekand T, Hagen EM, Grønning M.Spasticity following spinal cord injury[J]. Tidsskr Nor Laegeforen, 2012,132(8):970-973. DOI: 10.4045/tidsskr.10.0872.
[4]
Bearden DR, Monokwane B, Khurana E, et al.Pediatric cerebral palsy in botswana: etiology, outcomes, and comorbidities[J]. Pediatr Neurol, 2016,59:23-29. DOI: 10.1016/j.pediatrneurol.2016.03.002.
[5]
Van Naarden Braun K, Doernberg N, Schieve L, et al. Birth prevalence of cerebral palsy: a population-based study[J]. Pediatrics, 2016,137(1):1-9. DOI: 10.1542/peds.2015-2872.
[6]
Moltaji S, Novak CB, Dengler J.Nerve transfer surgery in spinal cord injury: online information sharing[J]. BMC Neurol, 2021,21(1):177. DOI: 10.1186/s12883-021-02209-5.
[7]
Fox IK, Davidge KM, Novak CB, et al.Nerve transfers to restore upper extremity function in cervical spinal cord injury: update and preliminary outcomes[J]. Plast Reconstr Surg, 2015,136(4):780-792. DOI: 10.1097/PRS.0000000000001641.
[8]
Allison R, Shenton L, Bamforth K, et al.Incidence, time course and predictors of impairments relating to caring for the profoundly affected arm after stroke: a systematic review[J]. Physiother Res Int, 2016,21(4):210-227. DOI: 10.1002/pri.1634.
[9]
Dvorak EM, Ketchum NC, McGuire JR. The underutilization of intrathecal baclofen in poststroke spasticity[J]. Top Stroke Rehabil, 2011,18(3):195-202. DOI: 10.1310/tsr1803-195.
[10]
Rhee PC.Surgical management of upper extremity deformities in patients with upper motor neuron syndrome[J]. J Hand Surg Am, 2019,44(3):223-235. DOI: 10.1016/j.jhsa.2018.07.019.
[11]
Xue W, Fan C, Chen B, et al.Direct neuronal differentiation of neural stem cells for spinal cord injury repair[J]. Stem Cells, 2021,39(8):1025-1032. DOI: 10.1002/stem.3366.
[12]
Lynn AK, Turner M, Chambers HG.Surgical management of spasticity in persons with cerebral palsy[J]. PM R, 2009,1(9):834-838. DOI: 10.1016/j.pmrj.2009.07.016.
[13]
Petersen MC, Palmer FB. Advances in prevention and treatment of cerebral palsy[J]. Ment Retard Dev Disabil Res Rev, 2001,7(1):30-37. DOI: 10.1002/1098-2779(200102)7:1<30::AID-MRDD1005>3.0.CO;2-2.
[14]
于炎冰,左焕琮,张黎,等.胫神经部分切断治疗脑瘫性踝痉挛[J].中国临床神经外科杂志,2002,7(4):217-219. DOI:10.13798/j.issn.1009-153x.2002.04.013Yu YB, Zuo HC, Zhang L, et al.Selective tibial neurotomy for relief of ankle spasticity in children with cerebral palsy[J]. Chinese Journal of Clinical Neurosurgery, 2002,7(4):217-219. DOI:10.13798/j.issn.1009-153x.2002.04.013.
[15]
于炎冰, 张黎, 马延山, 等. 选择性肌皮神经分支部分切断术治疗脑瘫性肘痉挛[J].中国微侵袭神经外科杂志,2005,10(10):449-450. DOI: 10.3969/j.issn.1009-122X.2005.10.007.Yu YB, Zhang L, Ma YS, et al.Selective partial neurotomy of musculocutaneous nerve for the treatment of elbow spasticity due to cerebral palsy[J]. Chinese Journal of Minimally Invasive Neurosurgery,2005,10(10):449-450. DOI: 10.3969/j.issn.1009-122X.2005.10.007.
[16]
Abbott R.The selective dorsal rhizotomy technique for spasticity in 2020: a review[J]. Childs Nerv Syst, 2020,36(9):1895-1905. DOI: 10.1007/s00381-020-04765-6.
Taira T, Hori T.Selective peripheral neurotomy and selective dorsal rhizotomy[J]. Brain Nerve, 2008,60(12):1427-1436.
[19]
Mittal S, Farmer JP, Al-Atassi B, et al.Long-term functional outcome after selective posterior rhizotomy[J]. J Neurosurg, 2002, 97(2):315-325. DOI: 10.3171/jns.2002.97.2.0315.
[20]
Westwell M, Ounpuu S, DeLuca P. Effects of orthopedic intervention in adolescents and young adults with cerebral palsy[J]. Gait Posture, 2009,30(2):201-206. DOI: 10.1016/j.gaitpost.2009.04.012.
[21]
Volpon JB, Natale LL.Critical evaluation of the surgical techniques to correct the equinus deformity[J]. Rev Col Bras Cir, 2019, 46(1):e2054. DOI: 10.1590/0100-6991e-20192054.
Limpaphayom N, Stewart S, Wang L, et al.Functional outcomes after selective dorsal rhizotomy followed by minimally invasive tendon lengthening procedures in children with spastic cerebral palsy[J]. J Pediatr Orthop B, 2020,29(1):1-8. DOI: 10.1097/BPB.0000000000000642.
[24]
Zhang SC, Johnston L, Zhang ZW, et al.Restoration of stepping-forward and ambulatory function in patients with paraplegia: rerouting of vascularized intercostal nerves to lumbar nerve roots using selected interfascicular anastomosis[J]. Surg Technol Int, 2003,11:244-248.
[25]
张少成,马玉海,Johnston L,等. 带血管肋间神经移位与骶神经根选择性束间吻接行截瘫患者尿便功能重建[J]. 中国临床康复, 2006, 10(17):190-192. DOI:10.3321/j.issn:1673-8225.2006.17.042.Zhang SC, Ma YH, Laurance J, et al.Reconstruction of bowel and bladder function in paraplegic patients by vascularized intercostal nerve transfer to sacral nerve roots with selected interfascicular anastomosis[J]. Chinese Journal of Clinical Rehabilitation, 2006,10(17):190-192. DOI:10.3321/j.issn:1673-8225.2006.17.042.
[26]
Zhang S, Wang Y, Johnston L.Restoration of function in complete spinal cord injury using peripheral nerve rerouting: a summary of procedures[J]. Surg Technol Int, 2008,17:287-291.
[27]
Zhang S, Ji F, Tong D, et al.Side-to-side neurorrhaphy for high-level peripheral nerve injuries[J]. Acta Neurochir (Wien), 2012, 154(3):527-532. DOI: 10.1007/s00701-011-1264-2.
[28]
Cui J, Gong X, Jiang Z, et al.Experimental study of the functional reserve of median nerve in rats[J]. Int J Clin Exp Med, 2015, 8(9):16015-16021.
[29]
Kingham PJ, Hughes A, Mitchard L, et al.Effect of neurotrophin-3 on reinnervation of the larynx using the phrenic nerve transfer technique[J]. Eur J Neurosci, 2007,25(2):331-340. DOI: 10.1111/j.1460-9568.2007.05310.x.
[30]
Bolívar S, Navarro X, Udina E. Schwann cell role in selectivity of nerve regeneration[J]. Cells, 2020,9(9)DOI: 10.3390/cells9092131.
[31]
Wilson TJ.Novel uses of nerve transfers[J]. Neurotherapeutics, 2019, 16(1):26-35. DOI: 10.1007/s13311-018-0664-x.
[32]
Papakonstantinou KC, Kamin E, Terzis JK.Muscle preservation by prolonged sensory protection[J]. J Reconstr Microsurg, 2002,18(3):173-184. DOI: 10.1055/s-2002-28469.
张少成,胡万坤,朱红伟,等.神经移位嫁接术臂丛神经功能重建[C]//创新•融合•共享——第五届北京国际康复论坛论文汇编(上册). 北京:中国康复研究中心,2010: 524-529.Zhang SC, Hu WK, Zhu HW, et al.Functional reconstruction of brachial plexus after nerve transfer graft surgery[C]// The 5th Beijing International Rehabilitation Forum. Beijing: China rehabilitation research center.2010: 524-529.
[35]
Ding W, Zhang S, Zhuo W, et al.Using nerve segment insert grafting to reconstruct neural pathways of brain-derived paralysis[J]. Translational Neuroscience and Clinics, 2017, 3(4):188-195. DOI:10.18679/CN11-6030/R.2017.028
[36]
Xu WD, Gu YD, Lu JB, et al.Pulmonary function after complete unilateral phrenic nerve transection[J]. J Neurosurg, 2005, 103(3):464-467. DOI: 10.3171/jns.2005.103.3.0464.
[37]
Jia X, Yang J, Yu C.Intercostal nerve transfer for restoration of the diaphragm muscle function after phrenic nerve transfer in total brachial plexus avulsion[J]. Clin Neurol Neurosurg, 2020, 197:106085. DOI: 10.1016/j.clineuro.2020.106085.
[38]
张少成,马玉海,党瑞山,等.带血管肋间神经与腰神经根选择性束间吻接行截瘫的迈步功能重建[J].中华国际医学杂志,2002,2(4):335-337. DOI:1606-7983(2002)04-0335-03.Zhang SC, Ma YH, Dang RS, et al.Reconstruction of stepping forward function for paraplegia by vascularized intercostal nerve transfer to lumbar nerve roots by selected interfascicular anastomosis[J]. Chin Int J Med, 2002;2(4):335-337. DOI:1606-7983(2002)04-0335-03.
[39]
张健,王文军,姚女兆,等.带血管肋间神经移位重建截瘫膀胱功能的初步临床应用[J].中国伤残医学,2013,21(5):8-10. DOI:10.3969/j.issn.1673-6567.2013.05.008.Zhang J, Wang WJ, Yao NZ, et al.Preliminary clinical studying of using intercostal nerve with vascular shift to reconstruct spinal cord injury with bladder dysfunction[J]. Chinese Journal of Trauma and Disability Medicine, 2013, 21(5):8-10. DOI:10.3969/j.issn.1673-6567.2013.05.008
[40]
王岩,张国强,张雪松,等.带血供尺神经转位重建截瘫患者下肢功能[J].中国脊柱脊髓杂志,2007,17(4):290-293. DOI:10.3969/j.issn.1004-406X.2007.04.022.Wang Y, Zhang GQ, Zhang XS, et al.Reconstruction of ambulance in patients with paraplegia by the ulnar nerve rerouted with anastomosed vessels[J]. Chinese Journal of Spine and Spinal Cord, 2007,17(4): 290-293 DOI:10.3969/j.issn.1004-406X.2007.04.022.
[41]
修先伦,王吉波,张少成,等.胫-腓总神经侧侧缝合治疗下肢痉挛性脑瘫近期效果观察[J].中国矫形外科杂志,2002,10(12):1187-1188. DOI:10.3969/j.issn.1005-8478.2002.12.014.Xiu XL, Wang JB, Zhang SC, et al.Treatment of spastic cerebral palsy by side-to-side neurorrhaphy of peroneal and tibial nerves[J]. Orthopedic Journal of China, 2002,10(12):1187-1188. DOI:10.3969/j.issn.1005-8478.2002.12.014.
[42]
马玉海,张少成,曹莉,等.家兔周围神经侧侧缝合的神经再生[J].中华国际医学杂志, 2002, 2(3):206-210. DOI:1606-7983(2002) 03-0206-05.Ma YH, Zhang SC, Cao L, et al.Experimental study of peripheral nerve regeneration after side-to-side neurorrhaphy in rabbits[J]. Chin Int J Med, 2002, 2(3):206-210. DOI: 1606-7983(2002) 03-0206-05.
[43]
修先伦, 张少成, 许硕贵,等. 神经血管疾患周围神经侧侧缝合法的实验研究[J].中华骨科杂志,2000,20(10):583. DOI: 10.3760/j.issn:0253-2352.2000.10.002Xiu XL, Zhang SC, Xu SG, et al.An experimental study of peripheral merve regeneration after side-to-side neurorrhaphy[J]. Chin J Orthop, 2000,20(10):583. DOI: 10.3760/j.issn:0253-2352.2000.10.002.
[44]
张少成, 马玉海, 孙来卿, 等. 神经束间侧侧缝接预防高位神经损伤后不可逆肌萎缩[J].中华创伤骨科杂志,2005,7(4):335-337, 340. DOI: 10.3760/cma.j.issn.1671-7600.2005.04.010.Zhang SC, Ma YH, Sun LQ, et al.Side-to-side neurorrhaphy of nerve tract to avoid irreversible atrophy of denervated skeletal muscle after superior peripheral nerve injury[J]. Chin J Orthop trauma, 2005,7(4):335-337,340. DOI: 10.3760/cma.j.issn.1671-7600.2005.04.010.
[45]
Yüksel F, Peker F, Celiköz B.Two applications of end-to-side nerve neurorrhaphy in severe upper-extremity nerve injuries[J]. Microsurgery, 2004,24(5):363-368. DOI: 10.1002/micr.20058.
[46]
张少成,禹宝庆,石志才,等.周围神经侧侧吻合治疗痉挛性脑瘫初步报告[J].中国矫形外科杂志,2000,7(11):1056-1058. DOI:10.3969/j.issn.1005-8478.2000.11.004.Zhang SC, Yu BQ, Shi ZC, et al.The treatment of cerebral palsy by side-to-side perepheral nerve anastomosis[J]. Orthopedic Journal of China, 2000, 7(11):1056-1058. DOI:10.3969/j.issn.1005-8478.2000.11.004.
[47]
张少成, 郭福玲, 阎国章, 等. 神经束间侧侧缝合重建截瘫/四肢瘫感觉功能[J].中国矫形外科杂志,2002,10(10):987-988. DOI: 10.3969/j.issn.1005-8478.2002.10.017.Zhang SC, Guo FL, Yan GZ, et al.Functional reconstruction of sensation in paraplegia with side to side suture interfascicular of peripheral nerves[J]. Orthopedic Journal of China,2002, 10(10): 987-988. DOI: 10.3969/j.issn.1005-8478.2002.10.017.