The progress of Raman spectroscopy in early diagnosis of osteoarthritis
Hu Lintao1, Zhang Xianzuo2, Luo Zhengliang2, Shang Xifu1
1Department of Orthopaedics, Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China; 2Department of Orthopaedics, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China
Abstract：Objective To summarize the progress of Raman spectroscopy in early diagnosis of osteoarthritis.Methods Using“拉曼光谱”“共焦拉曼光谱”“拉曼显微镜”“滴液沉积”“表面增强拉曼光谱”“光纤拉曼光谱”“拉曼光谱带”“骨关节炎”“软骨”“Raman spectroscopy”“Raman microspectroscopy”“confocal Raman spectroscopy”“drop deposition Raman spectroscopy” “surface-enhanced Raman spectroscopy”“fiber-optic Raman spectroscopy”“Raman bands”“osteoarthritis”and“cartilage”as the key words to identify the articles about Raman spectroscopy and its application in early diagnosis of osteoarthritis in CNKI, Wanfang and PubMed before December 2018. A total of 1 432 literatures were searched, and 34 literatures were finally included after excluding those with inconsistent content, inaccessible full text, repetitive research and design defects.Results Raman microspectroscopy, confocal Raman spectroscopy and fiber-optic Raman spectroscopy can evaluate the microscopic changes of cartilage in the early stage of osteoarthritis. Droplet deposition Raman spectroscopy and surface-enhanced Raman spectroscopy can provide diagnostic basis for synovial fluid and blood changes in early stage of osteoarthritis.Conclusions Raman spectroscopy has shown a brilliant application prospect in the early diagnosis of osteoarthritis, but its diagnostic standard and practicability still need to be further studied.
胡林涛, 张贤祚, 罗正亮, 尚希福. 拉曼光谱技术在骨关节炎早期诊断中的应用进展[J]. 中华解剖与临床杂志, 2020, 25(1): 82-86.
Hu Lintao, Zhang Xianzuo, Luo Zhengliang, Shang Xifu. The progress of Raman spectroscopy in early diagnosis of osteoarthritis. Chinese Journal of Anatomy and Clinics, 2020, 25(1): 82-86.
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2020, Vol. 25 
