Abstract：Objective To analyze the effect of fatty liver on liver transplantation postoperative earlier liver functions and assess the clinical outcomes and safety of fatty liver donor liver transplantation.Methods The clinical data of 26 patients with liver cancer who were under classical orthotopic transplantation surgery at Fuzhou General Hospital of Nanjing Milctary Command of Chinese PLA from January 2007 to March 2012 were retrospectively analyzed. Patients were divided into three groups according to donor liver′s pathological results and the levels of fattly liver: no fatty degeneration(normal group) 10 cases; mild fatty degeneration (mild group) 10 cases; moderate fatty degeneration (moderate group) 6 cases. The postoperative liver function recovery of each group was observed and compared.Results Three group patients were all under successful operation, no events in operation and none of PNF cases after surgery. The ALT, AST, PT and TBIL of mild group postoperative days 1, 3, 5, 7 and 14 showed no statistical significance (all P valuses＞0.05) compared with normal group, The level of ALT, AST and PT of moderate group postoperative days 1, 3 and 5 was higher than normal and mild groups (all P valuses＜0.05) while the level of TBIL showed no statistical significance (all P valuses＞0.05) comparied with normal and mild groups. The follow-up of 26 patients varied 20-75 months, average (38.6±18.2) months. The survivor of normal, mild and moderate groups after 1 year was 8 cases, 9 cases, 5 cases. And it showed no statistical significance(Hc=0.379, P=0.828).Coclusions Mild fatty donor liver showed no obviously unfavorable effect on postoperative early stage liver function, so it can be applied to clinical liver transplantation safely, the postoperative early stage liver function of moderate fatty liver donor liver patients recover slower than those of normal and mild fatty liver donor liver patients so it can be used to patients with better general conditions.
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2014, Vol. 19 
