Application of acoustic impulse radiation force technology combined with liver function and blood lipid in risk prediction of nonalcoholic fatty liver disease
Ren Tiantian*, Zhang Huiping, Wang Xiangqian, Yang Lufeng, Wen Yufeng, Wu Zewei.
*Department of Ultrasound, Ma'anshan People's Hospital, Ma'anshan 243000,China
Abstract：Objective To discuss the clinical value of virtual touch tissues quantification (VTQ) technique combined with indicators of liver function and blood lipid levels in risk prediction for non-alcoholic fatty liver disease (NAFLD) in acoustic radiation force impulse (ARFI).Methods A total of 189 inpatients with elastography, multi-slice spiral CT (MSCT) and laboratory tests at the People's Hospital of Ma'anshan from September 2016 to December 2016 were selected. Inclusion/exclusion criteria was guided by the 2010 Guidelines for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Diseases and the Results of MSCT. The study objects were divided into non-liver disease group and NAFLD group. Differences of VTQ, liver function and blood lipid indicators were analyzed and compared between control group and NAFLD group. Independent factors of Logistic regression coefficient were used to build nomogram model (with Bootstrap self-sampling for internal verification) to evaluate the risk of NAFLD.Results There were no statistical differences in age and sex between NAFLD group and non-liver disease group. The ratio of liver VTQ, liver/spleen VTQ, alanine transaminase(ALT), aspartate aminotransferase (AST) and triacylglycerol (TG) in NAFLD group were higher than those in non-liver disease group, but HDL was lower than that in non-liver disease group (all P values＜0.05). Remaining variables had no differences in statistics (all P values＞0.05). Multivariate logistic regression analysis had shown that liver VTQ (OR=8.054, 95%CI 2.117-30.639), ALT (OR=1.037, 95%CI 1.007-1.068) and TG (OR=1.500, 95%CI 1.042-2.159) were independent risk factors for NAFLD (all P values＜0.05). The nomogram was constructed with liver VTQ, ALT and TG as dependent variables and the C-index was 0.763.Conclusions VTQ as a noninvasive examination method can effectively diagnose NAFLD. Liver VTQ combined with ALT and TG can accurately provide risk value for NAFLD.
任恬恬, 张惠萍, 汪向前, 杨路锋, 文育锋, 伍泽伟. 声辐射力脉冲技术联合肝功能及血脂指标在非酒精性脂肪性肝病风险预测中的应用[J]. 中华解剖与临床杂志, 2018, 23(4): 340-344.
Ren Tiantian, Zhang Huiping, Wang Xiangqian, Yang Lufeng, Wen Yufeng, Wu Zewei.. Application of acoustic impulse radiation force technology combined with liver function and blood lipid in risk prediction of nonalcoholic fatty liver disease. Chinese Journal of Anatomy and Clinics, 2018, 23(4): 340-344.
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