Research Progress on the Intervertebral Disc Degeneration Model
SHAO Chen,ZHANG Chang-chun,Zhu Kun
Department of Orthopaedics,the first Affiliated Hospital of Bengbu Medical College,Anhui Key Laboratory of Tissue Transplantation,Bengbu,Anhui 233004,China
Abstract：Objective:To discuss the research and development of intervertebral disc degeneration model. Methods:To look for the related articles of the intervertebral disc degeneration model in the database of PubMed as well as CNKI, summarize and analyze those data.Results:Intervertebral disc degeneration model mainly includes in vitro model and in vivo model,the former includes intervertebral disc cell model and disc tissue model, the latter includes induced disc degeneration model and spontaneous disc degeneration model. In vitro model is widely applied, but which requires a high culture technique, and it can not simulate the in vivo environment fully; Intervention techniques can be more easily achieved in vivo culture, but it is narrowly applicable.Conclusions:Human intervertebral disc degeneration is affected by many factors; the current model of intervertebral disc degeneration often has certain limitation, which can not completely simulate human intervertebral disc degeneration. The intervertebral disc degeneration model, constructed by non-invasive, minimally invasive, will be the development trend in the future.
邵晨，张长春，朱坤作. 椎间盘退变模型的研究现状及进展[J]. 中华解剖与临床杂志, 2013, 18(1): 77-80.
SHAO Chen,ZHANG Chang-chun,Zhu Kun. Research Progress on the Intervertebral Disc Degeneration Model. Chinese Journal of Anatomy and Clinics, 2013, 18(1): 77-80.
2013, Vol. 18 
