Abstract：Objective To investigate the image for three-dimensional reconstruction of blood vessels in isolated placentas after using lead oxide or iopamidol as contrast agent.Methods A prospective study was conducted within 20 normal human placentas donated from puerperae without complications during pregnancy in the Second Hospital of Anhui Medical University from December 2015 to February 2016. The placentas were divided into two groups using simple random sampling and each group had ten placental samples. Lead oxide or iopamidol, mixed with colored self-curing denture base materials, was injected into both umbilical arteries and veins separately. Then CT scan was performed and post processing the images of placental blood vessels was completed using three-dimensional reconstruction technique. Placental volume, vascular volume and vessel diameters of different branches were measured using GE Adw 4.4 software. independent samples t test was used to analyze the data.Results The images of the first and second grade vascular branches of the placentas using lead oxide as contrast agent were in the strong three-dimensional sense without obvious artifacts, while the third and fourth grade vascular branches in the images looked blurred, and the microvascular of the placental lobular in the images looked sparse. On the contrary, the first and second grade vascular branches of the placentas in the images using iopamidol as contrast agent had no so strong three-dimensional sense, while the third and fourth grade vascular branches's perfusion had less peripheral vascular artifacts compared with the lead oxide group. The value of placental volume and vascular volume between the lead oxide and iopamidol groups had no significant differences (all P values>0.05). The value of the diameter in the first and second grade vascular branches in the lead oxide group was significantly greater than that in the iopamidol group, while the value of the diameter in the third and fourth grade vascular branches was obviously smaller than that in the iopamidol group (all P values<0.05).Conclusions Lead oxide is more suitable for displaying the three-dimensional reconstruction images in primary and secondary vascular branches of the placentas, while iopamidol is more suitable for displaying the three-dimensional reconstruction images in the third and fourth vascular branches of the placentas. Quantitative measurement of the three-dimensional reconstruction blood vessels may be used as a basic measurement during placental vascular research.
许有江, 李从青, 许玲, 李欢, 张妤, 卫兵, 王文艳. 氧化铅与碘帕醇造影剂在离体胎盘血管CT三维重建中的显影效果比较[J]. 中华解剖与临床杂志, 2017, 22(1): 1-5.
Xu Youjiang, Li Congqing, Xu Ling, Li Huan, Zhang Yu, Wei Bing, Wang Wenyan.. A comparison on contrast agents between lead oxide and iopamidol using for CT three-dimensional reconstruction of blood vessels in isolated placenta. Chinese Journal of Anatomy and Clinics, 2017, 22(1): 1-5.
Kawabe M, Sato A, Hoshi T, et al. Incremental value of B-type natriuretic peptide for detection and risk reclassification of obstructive coronary artery disease on computed tomography angiography[J]. J Cardiol, 2016, pii: S0914-5087(16)30135-6. DOI:10.1016/j.jjcc.2016.06.008
[4]
Ehrlich ME,Turner HL,Currie LJ,et al. Safety of computed tomographic angiography in the evaluation of patients with acute stroke: a single-center experience[J]. Stroke, 2016,47(8): 2045-2050.DOI:10.1161/STROKEAHA.116.013973
[5]
Bargellini I, Turini F, Bozzi E, et al. Image fusion of preprocedural CTA with real-time fluoroscopy to guide proper hepatic artery catheterization during transarterial chemoembolization of hepatocellular carcinoma: a feasibility study[J]. Cardiovasc Intervent Radiol, 2013, 36(2): 526-530. DOI:10.1007/s00270-012-0495-9
[6]
Khan AN, Khosa F, Nikolic B, et al. Cancerogenesis risks between 64 and 320 row detector CT for coronary CTA screening[J]. J Clin Imaging Sci, 2014, 4: 18. DOI:10.4103/2156-7514.131640
2017, Vol. 22 
