Clinical analysis of aggressive curettage with bone grafting and tumor resection with reconstruction for giant cell tumor of proximal femur
Li Shenglong1, Chen Peng2, Zheng Ke1, Wang Wei1, Pei Yi1, Zhang Xiaojing1
1Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China; 2the Graduate School, China Medical University, Shenyang 110122, China
Abstract:Objective To compare the clinical outcome of aggressive curettage with bone grafting and bone tumor resection with reconstruction of patients with proximal femoral giant cell tumor, and to analyzed the factors affecting rehabilitation of lower limb motor function, perioperative complications and tumor recurrence.Methods A retrospective analysis of 35 patients with giant cell tumor of the proximal femur was conducted in the Affiliated Tumor Hospital of China Medical University from January 2013 to December 2017.There were 18 male patients and 17 female patients, the average age was (39.85±11.59) years. According to the patient's tumor location, imaging classification and Giant Cell Tumor Team of China(GTOC) scores, patients received the treatment of aggressive curettage with bone grafting(15 patients) or bone tumor resection with reconstruction(20 patients). The patients received postoperative follow-up regularly. The duration of surgery, intraoperative blood loss, postoperative assisted walking time, short-term complications, Musculoskeletal Tumor Society(MSTS) scores of lower limb function and tumor recurrence were compared between the two procedures. The effects of pathological fracture, International Society of Limb Salvage(ISOLS) proximal tumor segmentation, Campanacci classification, surgical procedure and tumor volume on tumor relapse and lower limb function recovery were compared.Results All patients were followed up for 4-60(33.50±16.65) months. Two patients died of tumor metastasis at 6 and 8 months after surgery, and one patient died unexpectedly 6 months postoperative. The MSTS scores of lower limb function in patients with pathological fractures were 20.00±3.33, and in patients without pathological fractures were (22.88±3.81), there was significant different in statistics analysis (t=2.381, P<0.05). However, the amount of intraoperative blood loss [(316.55±80.35)mL vs.(384.53±76.37)mL] and short-term complications(2 vs. 8) were significantly higher in bone tumor resection and reconstruction group than in aggressive curettage with bone grafting group (t=2.530, χ2=7.887, P<0.05). There were no differences in the effects of surgical methods, presence of preoperative pathological fractures, ISOLS division, tumor volume, and Campanacci classification in tumor recurrence and lower limb function scores(all P values>0.05).Conclusions Aggressive curettage with bone grafting and bone tumor resection with reconstruction can achieve similar lower limbs functional recovery and the same level of tumor recurrence rate.Due to the larger orientation of the tumor resection and reconstruction, the intraoperative blood loss and short-term complications was higher. Preoperative pathological fractures had a negative impact on the recovery of postoperative lower limb function.
李盛龙, 陈朋, 郑珂, 王巍, 裴祎, 张晓晶. 扩大刮除植骨与瘤段切除重建治疗股骨近端骨巨细胞瘤的疗效分析[J]. 中华解剖与临床杂志, 2019, 24(3): 232-237.
Li Shenglong, Chen Peng, Zheng Ke, Wang Wei, Pei Yi, Zhang Xiaojing. Clinical analysis of aggressive curettage with bone grafting and tumor resection with reconstruction for giant cell tumor of proximal femur. Chinese Journal of Anatomy and Clinics, 2019, 24(3): 232-237.
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