Abstract:Objective To elaborate the important role of long noncoding RNA (LncRNA) in the regulation of tumor development and hypopharyngeal squamous cell carcinoma (HSCC).Methods Related publications with “长链非编码RNA,下咽癌/下咽鳞状细胞癌” “β-连环蛋白,下咽癌/下咽鳞状细胞癌” and “LncRNAs, tumor ” “LncRNAs, HSCC ”“Wnt/β-catenin ,EMT” “β-catenin, HSCC” were searched, analyzed and summarized in the database of CNKI, Wanfang Data, PubMed, Google academic, EMBASE database from January 2000 to September 2018 to review the role and molecular mechanism of LncRNAs in the development of HSCC. The mechanism of LncRNAs and Wnt pathway in the development of HSCC were reviewed. Altogether 3 297 related publications were searched and finally 48 papers were included according to the inclusion and exclusion criteria, containing 2 Chinese papers and 46 English papers.Results LncRNA were widely involved in the repair of DNA damage and physiological or pathological processes such as apoptosis, and plays an important role in the process of biological regulation. Wnt signaling pathway is an important cell signal transduction pathway, which plays an important role in cell proliferation and differentiation. The combination of LncRNAs and mRNA promoted the occurrence and development of HSCC. LncRNA promotes HSCC metastasis and recurrence through Wnt signaling pathway.Conclusions LncRNA are closely related to the pathogenesis of many disease, such as tumorigenesis. The occurrence and development of HSCC is regulated by LncRNA, and LncRNA plays an important role in the growth migration and invasion of HSCC tumor cells through Wnt signaling pathway.
孟洁, 王晓敏, 张明洁, 李慧, 陈德尚, 陆兆屹, 张俊杰, 李柏青, 马士崟. 长链非编码RNA及其在下咽鳞状细胞癌发生发展中的作用机制[J]. 中华解剖与临床杂志, 2018, 23(6): 564-568.
Meng Jie, Wang Xiaomin, Zhang Mingjie, Li Hui, Chen Deshang, Lu Zhaoyi, Zhang Junjie, Li Boqing, Ma Shiyin.. Long noncoding RNA and its role in the development and metastasis of hypopharyngeal squamous cell carcinoma. Chinese Journal of Anatomy and Clinics, 2018, 23(6): 564-568.
Qian Y, Liu D, Cao S, et al. Upregulation of the long noncoding RNA UCA1 affects the proliferation, invasion, and survival of hypopharyngeal carcinoma[J]. Mol Cancer, 2017, 16(1):68. DOI:10.1186/s12943-017-0635-6
[2]
Wiegand S, Esters J, Müller HH, et al. Is it necessary to dissect levels I and IIB in hypopharyngeal cancer?[J]. Acta Otolaryngol, 2010, 130(6): 747-752. DOI:10.3109/00016480903384168
[3]
Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions[J]. Nat Rev Genet, 2009, 10(3): 155-159. DOI:10.1038/nrg2521
[4]
Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional surprises from the RNA world[J]. Genes Dev, 2009, 23(13): 1494-1504. DOI:10.1101/gad.1800909
[5]
Li TT, He RQ, Ma J, et al. Long non-coding RNAs in small cell lung cancer: a potential opening to combat the disease (Review)[J]. Oncol Rep, 2018, 40(4): 1831-1842. DOI:10.3892/or.2018.6635
[6]
Wu Y, Wang YQ, Weng WW, et al. A serum-circulating long noncoding RNA signature can discriminate between patients with clear cell renal cell carcinoma and healthy controls[J]. Oncogenesis, 2016, 5: e192. DOI:10.1038/oncsis.2015.48
[7]
Hanly DJ, Esteller M, Berdasco M. Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer[J]. Philos Trans R Soc Lond B Biol Sci, 2018, 373(1748). pii: 20170074. DOI:10.1098/rstb.2017.0074
[8]
Lee C, Kikyo N. Strategies to identify long noncoding RNAs involved in gene regulation[J]. Cell Biosci, 2012, 2(1): 37. DOI:10.1186/2045-3701-2-37
[9]
Cesana M, Cacchiarelli D, Legnini I, et al. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA[J]. Cell, 2011, 147(2): 358-369. DOI:10.1016/j.cell.2011.09.028
[10]
Parasramka MA, Maji S, Matsuda A, et al. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma[J]. Pharmacol Ther, 2016, 161: 67-78. DOI:10.1016/j.pharmthera.2016.03.004
[11]
Chen LL. Linking long noncoding RNA localization and function[J]. Trends Biochem Sci, 2016, 41(9): 761-772. DOI:10.1016/j.tibs.2016.07.003
[12]
Yu Y, Yarrington RM, Chuong EB, et al. Disruption of promoter memory by synthesis of a long noncoding RNA[J]. Proc Natl Acad Sci USA, 2016, 113(34): 9575-9580. DOI:10.1073/pnas.1601793113
[13]
Prensner JR, Chinnaiyan AM. The emergence of lncRNAs in cancer biology[J]. Cancer Discov, 2011, 1(5): 391-407. DOI:10.1158/2159-8290.CD-11-0209
[14]
Gupta RA, Shah N, Wang KC, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis[J]. Nature, 2010, 464(7291): 1071-1076. DOI:10.1038/nature08975
[15]
Kogo R, Shimamura T, Mimori K, et al. Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers[J]. Cancer Res, 2011, 71(20): 6320-6326. DOI:10.1158/0008-5472.CAN-11-1021
[16]
Chen D, Wang J, Zhang Y, et al. Effect of down-regulated transcriptional repressor ZEB1 on the epithelial-mesenchymal transition of ovarian cancer cells[J]. Int J Gynecol Cancer, 2013, 23(8): 1357-1366. DOI:10.1097/IGC.0b013e3182a5e760
[17]
Li ZH, Gao J, Hu PH, et al. Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression[J]. Oncol Lett, 2017, 14(2): 1979-1984. DOI:10.3892/ol.2017.6418
[18]
Yang Z, Zhou L, Wu LM, et al. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation[J]. Ann Surg Oncol, 2011, 18(5): 1243-1250. DOI:10.1245/s10434-011-1581-y
[19]
Nie W, Ge HJ, Yang XQ, et al. LncRNA-UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p[J]. Cancer Lett, 2016, 371(1): 99-106. DOI:10.1016/j.canlet.2015.11.024
[20]
Huang JL, Ren TY, Cao SW, et al. HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma[J]. Oncotarget, 2015, 6(32): 33791-33804. DOI:10.18632/oncotarget.5667
[21]
Wang SH, Ma F, Tang ZH, et al. Long non-coding RNA H19 regulates FOXM1 expression by competitively binding endogenous miR-342-3p in gallbladder cancer[J]. J Exp Clin Cancer Res, 2016, 35(1): 160. DOI:10.1186/s13046-016-0436-6
[22]
Ribarska T, Goering W, Droop J, et al. Deregulation of an imprinted gene network in prostate cancer[J]. Epigenetics, 2014, 9(5): 704-717. DOI:10.4161/epi.28006
[23]
Chishima T, Iwakiri J, Hamada M. Identification of transposable elements contributing to tissue-specific expression of long non-coding RNAs[J]. Genes, 2018, 9(1): 23. DOI:10.3390/genes9010023
[24]
Matouk IJ, Abbasi I, Hochberg A, et al. Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis[J]. Eur J Gastroenterol Hepatol, 2009, 21(6): 688-692. DOI:10.1097/meg.0b013e328306a3a2
[25]
Gutschner T, Diederichs S. The hallmarks of cancer: a long non-coding RNA point of view[J]. RNA Biol, 2012, 9(6): 703-719. DOI:10.4161/rna.20481
[26]
Pasic I, Shlien A, Durbin AD, et al. Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma[J]. Cancer Res, 2010, 70(1): 160-171. DOI:10.1158/0008-5472.CAN-09-1902
[27]
Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease[J]. Cell, 2009, 139(5): 871-890. DOI:10.1016/j.cell.2009.11.007
[28]
Lepourcelet M, Chen YN, France DS, et al. Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex[J]. Cancer Cell, 2004, 5(1): 91-102. DOI10.1016/S1535-6108(03)00334-9
[29]
Qi J, Yu Y, AkilliÖztürk Ö, et al. New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals[J]. Gut, 2016, 65(10): 1690-1701. DOI:10.1136/gutjnl-2014-307900
[30]
Dijksterhuis JP, Baljinnyam B, Stanger K, et al. Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs[J]. J Biol Chem, 2015, 290(11): 6789-6798. DOI:10.1074/jbc.M114.612648
[31]
Tao H, Yang JJ, Zhou X, et al. Emerging role of long noncoding RNAs in lung cancer: current status and future prospects[J]. Respir Med, 2016, 110: 12-19. DOI:10.1016/j.rmed.2015.10.006
[32]
Hu W, Wang T, Yang Y, et al. Tumor heterogeneity uncovered by dynamic expression of long noncoding RNA at single-cell resolution[J]. Cancer Genet, 2015, 208(12): 581-586. DOI:10.1016/j.cancergen.2015.09.005
[33]
Chen T, Xie W, Xie L, et al. Expression of long noncoding RNA lncRNA-n336928 is correlated with tumor stage and grade and overall survival in bladder cancer[J]. Biochem Biophys Res Commun, 2015, 468(4): 666-670. DOI:10.1016/j.bbrc.2015.11.013
[34]
Zhou J, Li W, Jin T, et al. Gene microarray analysis of lncRNA and mRNA expression profiles in patients with hypopharyngeal squamous cell carcinoma[J]. Int J Clin Exp Med, 2015, 8(4): 4862-4882. DOI:10.1186/s12943-017-0635-6
Xiao C, Wu CH, Hu HZ. LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt beta-catenin signaling pathway[J]. Eur Rev Med Pharmacol Sci, 2016, 20(13):2819-2824. DOI: 10.18632/oncotarget.21884
[37]
Cheng H, Cui X, Guo Y, et al.The central role of HOTAIR in the malignancy of CD44 human hypopharyngeal carcinoma cells. Am J Transl Res 2016, 8: 5052-5058.DOI:1943-8141/AJTR0033225
[38]
Zhao M, Sun D, Li X, et al. Overexpression of long noncoding RNA PEG10 promotes proliferation, invasion and metastasis of hypopharyngeal squamous cell carcinoma[J]. Oncol Lett, 2017 Sep;14(3): 2919-2925. DOI:10.3892/ol.2017.6498
[39]
Deng X, Hu Y, Ding Q, et al. PEG10 plays a crucial role in human lung cancer proliferation, progression, prognosis and metastasis[J]. Oncol Rep, 2014 , 32(5): 2159-2167. DOI:10.3892/or.2014.3469
[40]
Pukkila MJ, Virtaniemi JA, Kumpulainen EJ, et al. Nuclear beta catenin expression is related to unfavourable outcome in oropharyngeal and hypopharyngeal squamous cell carcinoma[J]. J Clin Pathol, 2001, 54(1): 42-47. DOI:10.1136/jcp.54.1.42
Mu Y, Sa N, Yu L, et al. Epithelial cell adhesion molecule is overexpressed in hypopharyngeal carcinoma and suppresses the metastasis and proliferation of the disease when downregulated[J]. Oncol Lett, 2014, 8(1): 175-182. DOI:10.3892/ol.2014.2140
[43]
Kolenda T, Guglas K, Rys 'M, et al. Biological role of long non-coding RNA in head and neck cancers. Rep Pract Oncol Radiother. 2017 , 22(5):378-388. DOI: 10.1016/j.rpor.2017.07.001
[44]
Ren D, Li H, Li R, et al. Novel insight into MALAT-1 in cancer: therapeutic targets and clinical applications[J]. Oncol Lett, 2016, 11(3): 1621-1630. DOI:10.3892/ol.2016.4138