Abstract：Objective:To research the effects of vanillin smelling on the adjusting functions of depression and the possible functional mechanism through preparing the model of mouse depression of being raised separately, CUMS and being olfactory-organ-destroyed. Methods:60 male C57 mice were raised separately, they were treated with CUMS and destroy their olfactory organs, to prepare the model of depressed animals, to divide the mice into four groups of the fluoxetine, vanillin smelling, olfactory-organ-destroyed without the vanillin smelling treatment and olfactory-organ-destroyed with the vanillin smelling treatment, and to observe the nervous behavioral changes at different time and the concentration of 5-HT in the mice’s plasma after the treatment.Results:Two weeks after the treatment, the time of tail suspension test (TST) and forced swimming test (FST) shortened significantly(P＜0.05); four weeks after the treatment, the sucrose water consumption (SWC) increased significantly(P＜0.05); and through the treatment of vanillin smelling, the content of 5-HT in the mouse plasma was significantly improved (P＜0.05).Conclusions:Vanillin smelling can improve the nervous behavior of the depressed model mice and raise the content of 5-HT in the mouse plasma; the possible mechanism is that vanillin via olfactory pathway affect the metabolization of 5-HT loop, the activities in Hippocampus, amygdala and other brain areas and inhibit the reabsorption of 5-HT so that the depression can be prevented and cured.
王艳梅，许慧，徐金勇，李光武，徐胜春. 香草醛吸嗅对小鼠抑郁样行为的影响及其机制的探讨[J]. 中华解剖与临床杂志, 2013, 18(5): 394-397.
WANG Yan-mei,XU Hui,XU Jin-yong,LI Guang-wu,XU Sheng-chun. Effect of Vanillin Sinff on Relieving Depression-likeBehaviors in Mice and Discussion on the Possible Mechanism. Chinese Journal of Anatomy and Clinics, 2013, 18(5): 394-397.
2013, Vol. 18 
