Abstract：Objective To explore iodine concentration in non-tumor thyroid tissue of nodular goiter and papillary thyroid carcinoma, and to compare the different values of iodine concentration on normal thyroid with gemstone spectral CT. Methods Thirty-six cases(18 cases of papillary thyroid carcinoma and 18 cases of nodular goiter) with thyroid nodules were collected, nodules of which were all confirmed with surgical pathology in Peking University Shenzhen Hospital from August 2011 to July 2013. As a control group, 15 cases with suspected neck or cervical other unease, but normal function and structure of the thyroids were also included in this study. Image processing was performed on GSI Viewer browser to measure the different iodine concentration of thyroid tissue outside the lesion and normal thyroid. Statistical analysis was processed with Wilcoxon rank test and t-test. The distribution characteristics of the iodine concentration were explored as well. Results The differences of iodine concentration values were found between non-tumor tissue of papillary thyroid carcinoma and normal thyroid, as well as between non-tumor tissue of nodular goiter and normal thyroid (P＜0.05 in each group). The differences were not found between papillary thyroid carcinoma and nodular goiter (P＞0.05). Iodine concentration of thyroid tissue outside the lesion in nodular goiter and papillary thyroid carcinoma showed "U" type distribution. Conclusions Gemstone spectral CT, as a noninvasive method to detect iodine concentration in thyroid, will be helpful to reveal the relation between iodine concentration and thyroid disease.
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2014, Vol. 19 
