Abstract：Objective To explore new ideas for arteriosclerosis obliterans by observing the clinical efficacy of simvastatin in preventing preclinical arteriosclerosis obliterans developing.Methods One hundred and fifty-one elderly patients with preclinical arteriosclerosis obliterans were divided into control group(n=64) and experiment group(n=87):everyday life advising (vegetarian diet and moderate exercise and everyday life advising plus taking simvastatin (10 mg daily ). The carotid intima-media thickness(CIMT), ankle brachial index(ABI) and brachial-ankle pulse wave velocity(baPWV) were analyzed comparatively at 9 and 18 months after the treatment.Results There were no statistical differences in the CIMT, ABI and baPWV between the two groups before treatment(all P values>0.05). There was no statistical difference in the CIMT between the two groups at 9 and 18 months follow-up(all P values>0.05). There was no statistical difference in the ABI between the control group and experiment group at 9 months follow-up(P>0.05), but statistical difference at 18 months follow-up [(0.94±0.18) vs (0.90±0.18), P<0.05]. There were statistical differences in the baPWV between the control group and experiment group at 9 and 18 months follow-up [(1408.0±172.5)cm/s vs (1517.7±171.7)cm/s, (1381.1±176.1)cm/s vs (1501.7±185.3)cm/s, all P values<0.05].Conlusions Simvastatin can increase the ABI and decrease the baPWV. It has the efficacy to retard preclinical arteriosclerosis obliterans developing.
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Chen Shiyuan, Wang Xiaogao, Nie Zhonglin, Lu Ran, Guan Zheyu, Liu Chunjiang, Gao Yong.. The efficacy of simvastatin in preventing preclinical arteriosclerosis obliterans developing: A clinical study. Chinese Journal of Anatomy and Clinics, 2015, 20(2): 136-138.
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