The comparison study of the high resolution MRI and pathology of Han population with carotid atherosclerotic plaques
Qu Yang*, Xia Zhangyong, Zhao Zhenmei, Jiao Liqun, Chen Jun, Ban Ru, Huo Chengju, Wang Jiyue.
*Shandong Provine Cardio-Cerebrovascular Disease Mini-Invasive Therapy Engineering Technology Research Center, Department of Neurology, the People′s Hospital of Liaocheng, Liaocheng 252000, China
Abstract：Objective To explore the high resolution MRI of multi-sequence technology to evaluate carotid atherosclerotic plaques characteristics, and the accuracy of the assessment form, as well as the pathology factors which influence the stability of plaques.Methods One hundred and three patients with carotid endarterectomy were examined with carotid high-resolution MRI scanning of multiple sequence before surgery, and laque sections were detected with hematoxylin-eosin staining,Oil Red O staining,Masson staining and CD68 immuno- histochemistry after surgery. According to pathological Results, the patients were divided into vulnerable plaques group and stable plaques group, and the rasults were compared with MRI scanning Results.Results There were 42 cases with vulnerable plaques and 61 cases with stable plaques in 103 cases with carotid atherosclerotic plaques. Compared with the stable plaques group, the collagen content in vulnerable plaques group was significantly lower (10.37%±3.19% vs 17.02%±4.56%), while the lipid content was significantly higher (19.14%±3.26% vs 13.99%±3.47%), and the expression of CD68 increased significantly. The differences were statistically significant (t=8.169, 7.585, P<0.01). Compared with stable plaques, in vulnerable plaque group, the average lumen area, the minimum lumen area, the average wall area, the maximum wall area, the average wall thickness, the maximum wall thickness, the average standardized wall index and the maximum standardization wall index were significantly higher or lower. The differences were statistically significant(t=5.099, 7.513, 4.068, 2.535, 3.182, 3.503, 10.868, 6.233, all P values<0.05). Compared with the pathology group, MRI the detection rate of lipid-rich the necrotic core, plaque hemorrhage and calcification in carotid atherosclerotic plaque were lower, while the detection rate of surface rupture of the fibrous cap was higher. But there were no statistically significant differences (all P values>0.05).Conclusions There is significant difference between carotid atherosclerotic vulnerable plaques and stable plaques in pathological terms. Combining with high-resolution MRI of multi-sequence technology can be more accurate and more comprehensive to measur the wall structure, the composition and volume of plaque, which can be used for risk assessment of plaque.
曲旸, 夏章勇, 赵振美, 焦力群, 陈军, 班茹, 霍成举, 王继跃. 汉族人颈动脉粥样硬化斑块高分辨率MRI与病理特征的对照研究[J]. 中华解剖与临床杂志, 2016, 21(2): 94-100.
Qu Yang, Xia Zhangyong, Zhao Zhenmei, Jiao Liqun, Chen Jun, Ban Ru, Huo Chengju, Wang Jiyue.. The comparison study of the high resolution MRI and pathology of Han population with carotid atherosclerotic plaques. Chinese Journal of Anatomy and Clinics, 2016, 21(2): 94-100.
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2016, Vol. 21 
