Abstract：Objective To observe the effect of dexmedetomidine(DEX) on postoperative cognitive function in elderly patients with radical resection of rectal carcinoma with general anesthesia.Methods Sixty elderly patients scheduled for radical resection of rectal carcinoma were randomly divided into 2 groups: DEX group (n=30) and control group (n=30). All adopted intravenous anesthesia. The DEX given 2 ml (200 μg) was added 48 ml of saline, dubbed 4 mg/L solution. After the success of the endotracheal intubation, DEX 0.5 μg/kg was infused within 10 minutes in composited DEX group, then DEX was infused at rate of 0.5 μg·kg-1·h-1 until 30 minutes before the end of surgery, while saline 0.125 ml／kg was infused within 10 minutes in control group,then saline was infused at rate of 0.125 ml·kg-1·h-1 until 30 minutes before the end of surgery. Systolic pressure (SBP), diastolic pressure (DBP), heart rate (HR) were recorded before operation (T0), postoperative(T1), 5 min after extubation (T2), 30 min after extubation(T3). The time from the cessation of drugs to spontaneous breathing recovery time and to extubation time were also recorded. The cognitive function of patients in both groups were evaluated by mini-mental state examination(MMSE) at pre-operation and 24 h post-operation.Results Compared with T0, SBP and HR in DEX group decreased significantly from T1 to T3, SBP in control group increased from T1 to T3(all P values<0.05); compared with control group, SBP and HR in DEX group decreased significantly from T1 to T3(all P values<0.01).There were 2(6.7%) and 9(30.0%) cases of post cognitive dysfunction complicated in DEX group and control group, Comparison between the two groups had statistical significance(χ2=5.46, P<0.01).Conclusions DEX for elderly patients with colorectal cancer radical surgery can improve the postoperative cognitive function,and makes more stable hemodynamics for them
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Mei Mei, Wang Hong, Sun Jingjing. Effect of dexmedetomidine on postoperative cognitive function in elderly patients with radical resection of rectal carcinoma. Chinese Journal of Anatomy and Clinics, 2014, 19(5): 419-422.
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