摘要目的 应用7.0 T MRI显示妊娠中期胎儿标本眼球的解剖结构,获得胎儿眼球发育的正常测量值与其3D可视化模型,并分析测量值随孕龄的发育变化。方法 回顾分析2008年1月—2012年12月60例12~23周胎儿标本7.0 T MR扫描影像资料,于眼球最大水平断面测量近侧眼距、远侧眼距、眼球直径与晶状体直径。对图像应用Amira 4.1软件进行3D重建,获得其3D可视化模型及眼球体积与晶状体体积的测量值。分析上述测量值随胎龄变化的规律。结果 妊娠中期胎儿眼球及其附属结构可以清晰地在7.0 T MRI上辨认出来。诸径线测量值随胎龄增加呈对数增长,体积测量值随胎龄增加呈直线增长,R2为0.823~9.919。结论 7.0 T MRI可以较好地评价妊娠中期胎儿眼球发育,是对传统解剖学数据的补充,并可为临床评价宫内胎儿眼球发育正常与否提供指导。
Abstract：Objective To display the fetal eyeball anatomy in the second trimester with 7.0 T postmortem MRI, and obtain the normal morphological measurements and three-dimensional visualization model, then analyze the developmental changes with gestational age (GA).Methods Sixty specimens of 12-23 weeks GA were scanned using a 7.0 T MRI scanner. The globe diameter, lens diameter, interocular and binocular distances were measured on the transverse section with the biggest diameter of the eyeball. The three-dimensional visualization model was rebuilt with Amira 4.1 software. Then the globe and lens volume were obtained. All the measurements were plotted against GA.Results The fetal eyeball and its adjunct structures in the second trimester could be clearly delineated on 7.0 T postmortem MRI. All the linear measurements logarithmically increased with GA. However, the volumetric measurements linearly increased with GA.Conclusions 7.0 T postmortem MRI can clearly document fetal eyeball development in the second trimester. The quantitative data may be a valuable reference for the assessment of normal fetal eyeball development in clinical settings and as a supplement to anatomical investigations.
张忠和, 侯中煜, 林祥涛, 滕皋军, 孟海伟, 臧凤超, 冯蕾, 于乔文, 刘庆伟, 刘树伟. 妊娠中期胎儿眼球形态发育的标本MRI研究[J]. 中华解剖与临床杂志, 2015, 20(6): 519-522.
Zhang Zhonghe, Hou Zhongyu, Lin Xiangtao, Teng Gaojun, Meng Haiwei, Zang Fengchao, Feng Lei, Yu Qiaowen, Liu Qingwei, Liu Shuwei. MRI study on morphological development of fetal eyeball specimens in the second trimester. Chinese Journal of Anatomy and Clinics, 2015, 20(6): 519-522.
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